比较单径测量法与体积测量法评价晚期非小细胞肺癌化疗的疗效

发布时间：2018-06-06 09:20

本文选题：癌 + 非小细胞肺　；参考：《中国医学影像技术》2015年03期

【摘要】：目的比较单径测量法与体积测量法评估晚期非小细胞肺癌化疗疗效的一致性。方法回顾性分析104例接受化疗的晚期非小细胞肺癌患者化疗前及化疗2周期后的胸部增强CT扫描图像,对每例患者选取1~2个肺内病灶作为靶病灶,测量靶病灶的轴位最大长径、与其垂直的最大短径、冠状位垂直最大径及体积,根据轴位最大长径、体积的变化率分别进行疗效评价。记录每个病灶的形态学表现。结果 104例中,共85例(85/104,81.73%)采用体积测量与单径测量的评价结果一致、二者的评价呈中度一致(Kappa值为0.520)。单径测量评价为疾病稳定(SD)的85例患者中,评价结果一致组与不一致组间治疗前后形态变化、轴位垂直短径变化率、高度变化率的差异均有统计学意义(P均0.05)。结论在晚期非小细胞肺癌化疗疗效评估中,单径测量法与体积测量法的评价结果一致性为中度。
[Abstract]:Objective to compare the efficacy of single path measurement and volume measurement in the evaluation of chemotherapeutic efficacy of advanced non-small cell lung cancer (NSCLC). Methods chest enhanced CT images of 104 patients with advanced non-small cell lung cancer (NSCLC) receiving chemotherapy before and after 2 cycles of chemotherapy were retrospectively analyzed. 1 ~ 2 lung lesions were selected as target lesions in each patient. The axial maximum length of the target lesions was measured. The curative effect was evaluated according to the maximum axial length and volume with the maximum vertical short diameter and coronal maximum diameter and volume. The morphological features of each lesion were recorded. Results of 104 cases, 85 cases (85 / 104 / 81.73) were evaluated by volume measurement and single diameter measurement, and the Kappa value was 0.520%. In 85 patients with SDD, there were significant differences in morphological change, axial vertical short diameter change rate and height change rate before and after treatment between the same group and the inconsistent group (P < 0.05). Conclusion in the evaluation of chemotherapeutic efficacy of advanced non-small cell lung cancer, the evaluation results of single path measurement and volume measurement are moderate.
【作者单位】：北京清华长庚医院放射科;北京大学临床肿瘤学院;北京肿瘤医院;北京市肿瘤防治研究所医学影像科恶性肿瘤发病机制及转化研究教育部重点实验室;
【基金】：国家重点基础研究发展计划(973计划)(2006CB705700)
【分类号】：R730.44;R734.2

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