糖耐量正常试验者及糖耐量异常患者的全肝脂肪MRI定量研究

发布时间：2018-06-17 09:51

本文选题：脂肪肝 + MR脂肪定量　；参考：《中山大学学报(医学科学版)》2015年03期

【摘要】：【目的】利用MR定量测定糖耐量正常(NGT)试验者及糖耐量异常(IGT)患者的全肝脂肪含量,分析该两类人群的全肝脂肪含量与临床指标之间的相关性。【方法】收集NGT及IGT患者共63例,行上腹部MRI检查,其中有T1WI DIXON序列,其中42例NGT,21例为IGT患者。NGT组再根据体质量指数(BMI)分为NGT-Fat(BMI≥25,18例)和NGT-Lean(BMI25组,24例)。测量并计算每个受试者的全肝脂肪含量(FVF),并对全肝脂肪含量与相应临床及实验室检查结果进行统计相关性研究,同时对IGT组,NGT-Fat组和NGT-Lean组之间的肝脏脂肪含量差异进行评价。【结果】所有受试者的FVF值范围从4.2%到28.8%。FVF值与BMI(P=0.005),腰臀比(WHR,P=0.0 44),低密度脂蛋白胆固醇(LDL-C,P=0.033),空腹血浆胰岛素(FPI,P=0.018),胰岛素抵抗指数(HOMA-IR,P=0.018)及胰岛β细胞指数(HOMAβ,P=0.005)呈正相关。IGT组和NGTFat组的FVF值显著高于NGT-Lean组(P=0.003,0.006)。【结论】高BMI、WHR及LDL-C的个体全肝脂肪含量较高。BMI≥25的个体更有可能发展为IGT。FVF值较高的个体表现出更高的胰岛素抵抗性,具有更高的风险发展为2型糖尿病。
[Abstract]:[Objective] to determine the total liver fat content of patients with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT), and to analyze the correlation between the total liver fat content and clinical indexes of the two groups of people. [Methods] 63 cases of NGT and IGT were collected and the upper abdominal MRI examination was performed, including T1WI DIXON sequence, of which 42 cases NGT, 21 cases. The.NGT group of IGT patients was divided into NGT-Fat (BMI > 25,18 cases) and NGT-Lean (BMI25 group, 24 cases). The total liver fat content (FVF) was measured and calculated, and the total liver fat content was correlated with the corresponding clinical and laboratory examination results, and between IGT, NGT-Fat and NGT-Lean groups. The difference in liver fat content was evaluated. [results] the FVF value of all subjects ranged from 4.2% to 28.8%.FVF with BMI (P=0.005), waist to hip ratio (WHR, P=0.0 44), low density lipoprotein cholesterol (LDL-C, P=0.033), fasting plasma insulin (FPI, P=0.018), islet resistance index (HOMA-IR, P=0.018), and islet beta cell index. The FVF values in the positive correlation.IGT group and the NGTFat group were significantly higher than those in the group NGT-Lean (P=0.003,0.006). [Conclusion] individuals with high BMI, WHR and LDL-C with higher.BMI more than 25 are more likely to develop to higher IGT.FVF values with higher insulin resistance, with a higher risk of developing type 2 diabetes.
【作者单位】：中山大学附属第一医院医学影像科;
【基金】：国家自然科学基金青年(81000626) 广东省自然科学基金(S2013010016004) 珠江科技新星专项(2012J2200084) 中央高校基本科研业务费专项资金(10ykpy11)
【分类号】：R587.1;R445.2

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