磁共振弥散加权成像预测出血性转化实验研究

发布时间：2018-06-21 06:43

  本文选题：出血性转化 + 弥散加权成像　； 参考：《中国医学计算机成像杂志》2016年04期

【摘要】：目的:探讨3.0T磁共振弥散加权成像(DWI)中表观弥散系数(ADC)值及指数表观弥散系数(e ADC)值对兔急性脑缺血性脑卒中出血性转化(HT)的预测价值。方法:37只新西兰大白兔颈内动脉注射自体血栓制备急性脑缺血性脑卒中模型,模型制备3.5h时行DWI检查,模型制备成功者,术后4h行尿激酶静脉溶栓。模型成功72h后处死动物,行HE染色。应用SPSS16.0统计学软件,采用独立样本t检验比较无HT组与HT组之间ADC值、e ADC值的差异有无统计学意义。结果:27只新西兰大白兔急性缺血性脑卒中模型制作成功,其中6例发展为HT,HI型5例,PH型1例。无HT组3.5h梗死区ADC值为(0.752±0.114)×10-3mm~2/s,HT组ADC值为(0.482±0.068)×10~(-3)mm~2/s,两组ADC值的差异有统计学意义(P=0.000)。无HT组3.5h梗死区e ADC值为0.479±0.053,HT组e ADC值为0.618±0.074,两组e ADC值的差异有统计学意义(P=0.000)。结论:缺血性脑卒中急性期ADC值、e ADC值的改变与HT的发生存在一定相关性,ADC值越低、eADC值越高则HT发生的可能性就越大,这对临床溶栓治疗的预后判断有一定的参考意义。
[Abstract]:Objective: to study the predictive value of apparent diffusion coefficient (ADCC) and exponential apparent diffusion coefficient (e ADCV) in DWI of 3.0T magnetic resonance diffusion weighted imaging (DWI) for hemorrhagic transformation of acute cerebral ischemic stroke in rabbits. Methods the acute cerebral ischemic stroke model was established by injecting autologous thrombosis into the carotid artery of 37 New Zealand white rabbits. DWI was performed at 3.5 hours after the preparation of the model, and urokinase thrombolysis was performed 4 hours after the operation. After 72 hours of success, the animals were killed and stained with HE. Using SPSS 16.0 statistical software, the difference of ADC value between HT group and HT group was compared by independent sample t test. Results the acute ischemic cerebral apoplexy model of 27 New Zealand white rabbits was established successfully, of which 6 cases developed into 5 cases of HT HI type and 1 case of PH type. The ADC value of infarct area in the no HT group at 3.5 h was 0.752 卤0.114) 脳 10 ~ (-3) mm ~ (-2) / s. The ADC value of the two groups was 0.482 卤0.068) 脳 10 ~ (-3) mm ~ (-3) / s. The difference of ADC value between the two groups was statistically significant (P < 0.05). The eADC value in the infarct area of the no HT group was 0.479 卤0.053% (0.618 卤0.074), and the difference between the two groups was statistically significant (P < 0.05). Conclusion: there is a certain correlation between the change of ADC value and the occurrence of HT in the acute phase of ischemic stroke. The lower the ADC value is, the higher the ADC value is, the more likely it will be, which is useful for the prognosis of thrombolytic therapy.
【作者单位】： 江苏省徐州市中心医院CT室;江苏省徐州医学院附属医院影像科;
【基金】：徐州市科技计划项目KC14SH019~~
【分类号】：R445.2;R743.3
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本文编号：2047632