肝癌的DCE-MRI定量成像与微血管密度、Ki-67相关性研究

发布时间：2018-06-21 14:06

本文选题：微血管密度 + 肝细胞癌　；参考：《临床放射学杂志》2017年11期

【摘要】：目的探讨肝癌MRI多期动态对比增强(DCE-MRI)灌注定量参数与微血管密度(MVD)、Ki67相关性。方法对37例经手术病理确诊肝细胞癌(HCC)患者进行自由呼吸下行全肝MRI灌注扫描,将所获得HCC灌注定量参数K~(trans)、K_(ep)、V_e、V_p值及微血管密度(MVD)、Ki-67进行统计学对照分析。结果 37例HCC患者中,病理分级高分化6例,中分化20例,低分化11例。高分化HCC K~(trans)、K_(ep)、V_e、V_p值分别是(1.09±1.40)min~(-1)、(3.04±3.08)min~(-1)、0.917±1.06、0.46±0.33,MVD 75.67±8.44,Ki-67 25.84±8.43。中分化HCC K~(trans)、K_(ep)、V_e、V_p值分别是(0.96±1.06)min~(-1)、(2.90±2.04)min~(-1)、0.620±0.67、0.12±0.09,MVD 66.43±11.19,Ki-67 41.50±1.99。低分化HCC K~(trans)、K_(ep)、V_e、V_p值分别是(0.58±0.59)min~(-1)、(2.08±1.36)min~(-1)、0.48±0.36、0.17±0.17,MVD 54.92±22.43,Ki-67 47.55±2.14。Ki-67与病理分级呈正相关(r=0.369,P=0.034);灌注定量参数K~(trans)、K_(ep)值与肿瘤MVD呈明显正相关(r值分别为0.765和0.747,P值均为0.000)。结论 DCE-MRI定量分析能够对肝癌内血管特性进行准确评估,为评价肿瘤组织的微循环功能状态提供新的诊断方法。
[Abstract]:Objective to investigate the correlation between the quantitative parameters of DCE-MRI perfusion and microvessel density (MVDX) 67 in multiphase dynamic contrast enhanced Mr imaging (MRI) of hepatocellular carcinoma (HCC). Methods Total hepatic MRI perfusion scan was performed in 37 patients with hepatocellular carcinoma (HCC) confirmed by operation and pathology. The quantitative parameters of HCC perfusion were compared and analyzed statistically. Results in 37 patients with HCC, 6 cases were well differentiated, 20 cases were moderately differentiated and 11 cases were poorly differentiated. The Vapor value of highly differentiated HCC was 1.09 卤1.40 min / L (3.04 卤3.08 min / L) respectively. The MVD was 0.917 卤1.06U 0.46 卤0.33 MVD 75.67 卤8.4Ki-67 25.84 卤8.43. The Vapor value of moderately differentiated HCC was 0.96 卤1.06min / min (2.90 卤2.04min) and 0.620 卤0.670.12 卤0.09MVD 66.43 卤11.19MVD 66.43 卤11.19MVD 66.43 卤11.1941.50 卤1.99respectively0.90 卤2.04min ~ (-1) ~ (-1) ~ 0.20 卤0.670 ~ (0.12 卤0.09) MVD 66.43 卤11.19 ~ 41.50 卤1.99 respectively. The Vaporp values of low differentiated HCC patients were 0.58 卤0.59 min-1 and 0.48 卤0.36 min / L respectively. The MVD of 0.48 卤0.36 MVD 54.92 卤22.43 Ki-67 卤2.14.Ki-67 were positively correlated with the pathological grade, and the quantitative parameters of perfusion were 0.369P0.034, respectively. The correlation between the quantitative parameters of perfusion and the tumor MVD was 0.765 and 0.747g, respectively. Conclusion the quantitative analysis of DCE-MRI can accurately evaluate the vascular characteristics of hepatocellular carcinoma and provide a new diagnostic method for evaluating the function of microcirculation in tumor tissues.
【作者单位】：广东省东莞市人民医院放射科;东莞市厚街医院超声科;广东省东莞市人民医院病理科;
【分类号】：R445.2;R735.7

【相似文献】