食管癌三维适形放疗GTV-T体积与临床分期及预后的相关性分析

发布时间：2018-06-25 10:03

  本文选题：GTV-T体积 + 临床分期　； 参考：《肿瘤防治研究》2015年07期

【摘要】：目的探讨应用肿瘤体积大小评价食管癌临床分期标准的准确性、符合程度及其与预后的关系。方法分析接受根治性三维适形放疗(three-dimensional conformal radiotherapy,3DCRT)的375例食管癌患者临床资料,选择合适的GTV-T体积分级标准,结合区域淋巴结转移情况进行临床分期,并结合患者预后进行分析。结果与病理T分期对应,将GTV-T体积按≤30 cm3、30~≤60 cm3、60~90cm3、90 cm3分为T1、T2、T3、T4四级,5年生存率之间比较,T3与T4级之间差异无统计学意义(P=0.556),而按T1、T2、T3+4三分级,各T分级之间的生存差异有统计学意义(P0.001)。无区域淋巴结转移N0者较有区域或非区域淋巴结转移N1~2者预后好(P=0.000)。对应GTV-T体积T1、T2、T3+4三分级,将食管癌临床分期对应分为Ⅰ、Ⅱ、Ⅲ期,将出现N2期或远处转移的患者,全部归入Ⅳ期,各期生存差异具有统计学意义(P0.001)。结论 GTV-T按T1、T2、T3+4三分级法能较好地反映预后生存;对应GTV-T三分级的临床四分期法,亦能较好的反应预后。
[Abstract]:Objective to evaluate the accuracy, degree of coincidence and prognosis of clinical staging criteria for esophageal carcinoma by using tumor volume. Methods the clinical data of 375 patients with esophageal carcinoma receiving three-dimensional conformal radiotherapymetric 3DCRT were analyzed. The appropriate GTV-T volumetric grading criteria were selected and the clinical staging was performed in combination with regional lymph node metastasis and the prognosis of the patients was analyzed. Results according to pathological T stage, GTV-T volume was divided into T _ 1 T _ 2 and T _ 3 ~ T _ 4 grade according to 鈮，

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