轻型脑外伤患者脑网络中心度改变的静息态fMRI研究

发布时间：2018-07-05 01:13

本文选题：轻型脑外伤 + 静息态功能磁共振成像　；参考：《临床放射学杂志》2015年12期

【摘要】：目的采用基于体素的节点中心度(DC)探讨轻型脑外伤(MTBI)患者功能脑网络组体素水平节点单元拓扑属性的变化特点。方法对13例轻型脑外伤患者(MTBI组)及与之年龄、性别相匹配的15例健康志愿者(正常对照组)行静息态功能磁共振扫描(R-f MRI)及临床相关量表评分,使用SPM 8及DPARSFA在Matlab 2012b平台上采用基于体素的DC(相关系数r阈值为0.25,二值化连边矩阵)方法分析R-f MRI数据;采用卡方检验及t检验比较组间参数,对MTBI组差异脑区的DC值分别与临床参数进行相关性检验。结果与正常对照组相比,MTBI组右侧额上回DC值增高;右侧颞中回、双侧顶下小叶、左侧小脑半球DC值显著减低(P0.05,GRF多重校正)。右侧额上回的DC值与运动功能评估量表(r=0.77)正相关,与格拉斯哥昏迷量表(r=-0.75)、日常生活能力量表(r=-0.76)负相关。左侧顶下小叶(缘上回)DC值与简易智力量表(r=0.64)正相关。结论 MTBI患者DC的改变及其与临床参数的关联,提示其神经认知功能改变的功能脑网络基础。
[Abstract]:Objective to investigate the characteristics of the topological properties of histone horizontal node units in functional brain network (MTBI) patients with mild brain trauma (MTBI) by voxel based node centrality (DC). Methods resting functional magnetic resonance imaging (R-f MRI) and clinical related scales were performed in 13 patients with mild brain injury (MTBI group) and 15 healthy volunteers matched with age and sex (normal control group). Using SPM8 and DPARSFA to analyze R-f MRI data on Matlab 2012b platform, using voxel based DC (correlation coefficient r threshold is 0.25, binary-connected matrix), comparing parameters between groups by chi-square test and t-test. The correlation between DC values and clinical parameters of different brain regions in MTBI group was tested. Results compared with the control group, the DC values of right superior frontal gyrus in MTBI group were increased, and the DC values in right middle temporal gyrus, bilateral inferior parietal lobules and left cerebellar hemisphere were significantly decreased (P0.05 GRF multiple correction). The DC value of the right superior frontal gyrus was positively correlated with the motor function assessment scale (rm0.77), negatively correlated with the Glasgow coma scale (r-0.75) and the activity of daily living scale (r-0.76). DC values in the left inferior parietal lobule (supramarginal gyrus) were positively correlated with the mini-intelligence scale (r = 0.64). Conclusion the changes of DC and its correlation with clinical parameters in MTBI patients suggest the functional brain network basis for neurocognitive changes.
【作者单位】：南昌大学第一附属医院影像科;
【基金】：国家自然科学基金资助项目(81260217)
【分类号】：R445.2;R651.15

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