正常功能移植肾功能磁共振的影像学表现

发布时间：2018-07-06 13:27

本文选题：移植肾 + BOLD　；参考：《浙江大学》2014年硕士论文

【摘要】：研究背景及目的：通过对探讨功能正常移植肾BOLD及DWI-MRI的表现,并对其功能磁共振表现做一综合性评价,以期为功能磁共振在移植肾功能评价的应用提供依据。方法： 1.采集15例健康志愿者的肾脏功能磁共振表现作为对照组,为观察移植肾功能磁共振的改变奠定对照基础。 2.分析一组(N=12)临床及化验室检查证实功能正常的移植肾进行功能磁共振检查,测量移植肾的数据。根据移植后时间分为三组：第一组移植后半个月；第二组移植后1个月；第三组移植后18个月。 3.利用统计学软件分析,对不同时段移植肾进行比较,并将移植肾与健康对照组进行统计学分析。 4.分析统计学结果的异同点,讨论BOLD及DWI-MRI在移植肾功能检测的价值。结果： 1.健康对照组皮质R2*(1/sec)值为17.86±1.228/sec,髓质R2*(1/sec)值为33.216+7.948/sec,髓质明显高于皮质,皮髓质具有显著性差异(P0.05)。皮髓质R2*值比值为0.565±0.128。 2.移植肾组,半个月组与1个月组皮髓质R2*值无明显统计学差异。而18个月组髓质R2*值明显增高,与半个月组及1个月组有显著统计学差异(P0.05),而皮质R2*值无明显统计学差异。与健康对照组相比,移植肾组出皮质与髓质R2*值均出现了显著统计学差异(P0.05)。 3.ADC值经统计学分析发现,18个月组ADC值均低于前2组,具有显著统计学差异(P0.05)。半个月组和18个月组,与健康对照组对比,出现显著统计学差异(P0.05)。结论： 1. ADC DWI及BOLD MRI可以更加灵敏及时的反应肾脏氧代谢的改变。 2.随着移植后时间的延长,移植肾氧耗量表观趋于稳定,但水分子的运动出现缓慢的、逐渐受限加重的趋势。ADC DWI及BOLD MRI可以及早的反应肾脏功能变化的情况,早于实验室检查及肾小管滤过率等的结果,是一种更加简单、无创的检查手段。
[Abstract]:Background and objective: to investigate the findings of bod and DWI-MRI in normal renal transplantation and to evaluate their functional MRI in order to provide basis for the application of functional magnetic resonance imaging (fMRI) in the evaluation of renal allograft function. Methods: 1. Renal functional magnetic resonance imaging (fMRI) findings of 15 healthy volunteers were collected as control group. A group of renal grafts with normal function confirmed by clinical and laboratory tests were analyzed. According to the time after transplantation, the first group was divided into three groups: the first group was half a month after transplantation, the second group was 1 month after transplantation, and the third group was 18 months after transplantation. Statistical software analysis was used to compare the transplanted kidney at different time periods, and statistical analysis was made between the transplanted kidney and the healthy control group. 4. 4. The differences and similarities of statistical results were analyzed and the value of bold and DWI-MRI in the detection of renal allograft function was discussed. Results: 1. The cortical R2 * (1/sec) and medullary R2 * (1/sec) of the healthy control group were 17.86 卤1.228 / secand 33.216 7.948 / sec.The medullary substance was significantly higher than that of the cortex (P0.05). The ratio of R2 * value of skin medulla was 0.565 卤0.128.2. There was no significant difference in R2 * value of skin medulla between half month group and 1 month group. The medullary R2 * value in 18-month group was significantly higher than that in half-month group and 1-month group (P0.05), but there was no significant difference in cortex R2 * value. Compared with the healthy control group, the R2 * values of cortex and medulla in renal transplantation group were significantly different (P0.05). 3. After statistical analysis, the ADC values of 18 months group were lower than those of the first two groups, with significant statistical difference (P0.05). Half a month group and 18 months group, compared with the healthy control group, there was significant statistical difference (P0.05). Conclusion: 1. ADC DWI and bold MRI can more sensitive and timely response to changes in renal oxygen metabolism. 2. With the extension of time after transplantation, the oxygen consumption scale of transplanted kidney tended to be stable, but the movement of water molecules was slow and gradually restricted. ADC DWI and bold MRI could reflect the changes of renal function as early as possible. Earlier than the results of laboratory examination and renal tubular filtration rate, it is a simpler, non-invasive method.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2;R699.2

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