声脉冲辐射力成像技术评估肝细胞癌射频消融术后24 h疗效的价值

发布时间：2018-07-15 09:30

【摘要】：目的 :探讨声脉冲辐射力成像技术(Acoustic radiation force impulse,ARFI)对评估肝细胞癌(Hepathocellular carcinoma,HCC)射频消融(Radiofrequency ablation,RFA)术后24 h疗效的临床价值。材料与方法 :2015年12月—2016年6月我院行RFA治疗22例患者共23个HCC病灶纳入本研究。分别于RFA术前1 d、术后24 h及术后1月行常规超声、超声造影(Contrast enhanced ultrasound,CEUS)及ARFI检查,观察消融灶硬度变化,对比3种方法对消融灶范围的显示情况。结果:23个消融灶RFA术后24 h及术后1月ARFI弹性图均表现为黑暗色(质硬),较术前质硬,边界清晰,范围增大。术后24 h消融灶内部及边缘ARFI弹性值较术前显著升高,差异有统计学意义(P0.01,P0.01),与术后1月比较无统计学差异(P=0.46,P=0.50);术后24 h及术后1月消融灶周边肝实质ARFI弹性值较术前无统计学差异(P=0.74,P=0.92)。术后24 h及术后1月ARFI与CEUS显示面积的大小比较均无统计学差异(P=0.88,P=0.49),与常规超声比较差异有统计学意义(P0.01,P0.01)。结论 :ARFI能够清晰显示RFA术后24 h消融灶范围,与CEUS结果相似,优于常规超声,并能定量反应消融灶硬度变化情况。
[Abstract]:Objective: to evaluate the clinical value of (Acoustic radiation force impulse radiography (ARFI) in evaluating the effect of radiofrequency ablation (RFA) on hepatocellular carcinoma (HCC) 24 hours after radiofrequency ablation (RFA). Materials and methods: 23 HCC lesions were treated with RFA from December 2015 to June 2016. Conventional ultrasound, Contrast enhanced ultrasound (CEUs) and ARFI were performed 1 day before, 24 hours after operation and 1 month after RFA, respectively. The hardness of ablation focus was observed and the extent of ablation was compared with the three methods. Results: 24 hours after RFA and 1 month after RFA, 23 ablation foci showed dark color (hard), clear boundary and wide range. At 24 hours after operation, the elastic value of ARFI was significantly higher than that of preoperative ablation. The difference was statistically significant (P0.01, P0.01), but there was no significant difference between P0. 46 and P0. 50, but there was no significant difference in ARFI elasticity between 24 hours after operation and 1 month after ablation (P0. 74 and P0. 92). There was no significant difference in the display area between ARFI and CEUs 24 hours after operation and 1 month after operation (P < 0. 88), but there was a significant difference between ARFI and CEUs (P0. 01, P0. 01). Conclusion the range of ablation foci at 24 hours after RFA can be clearly demonstrated by WARFI, which is similar to CEUs, superior to conventional ultrasound, and can quantitatively reflect the change of ablation focus hardness.
【作者单位】：广西医科大学第一附属医院;
【基金】：国家自然科学基金资助项目(编号81060202,81260222) 广西卫生厅重点课题(编号桂卫重2011089)
【分类号】：R445.1;R735.7

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