MR灌注成像与多参数对缺血性脑血管病的应用研究
发布时间：2018-07-17 19:36
【摘要】：目的：1.评价DWI与PWI在不同时期脑梗死中联合应用的价值。2.探讨不同时期脑梗死灶ADC值及超、急性期不同位置ADC值的变化规律。3.探讨不同时期脑梗死灶的FA值变化及其对脑白质纤维束的影响。 方法：收集从2012年11月～2014年3月来我院就诊的脑梗死患者63例，其中男性患者35例，女性28例;年龄区间为30～88岁，平均年龄为61.3岁。分别包括发病在6小时以内超急性期的脑梗死患者8例，，6～72小时急性期的脑梗死患者12例，3～10天亚急性期的脑梗死患者25例，10天以上慢性期的脑梗塞患者18例。所有患者行MR常规T1flair、T2WI、T2flair、DWI、DTI、PWI扫描。逐个测量患侧和对侧相应区域的ADC，患侧和对侧相应区域的FA值，超、急性期患者梗死灶中心、边缘和周围ADC值，由两名经验丰富的影像科医师判读DWI与PWI图的匹配情况以及DTT图的白质纤维束的受损情况。 结果：本研究中PWIDWI的病例数为16例，DWI≈PWI的病例数为44例，PWIDWI的病例数为3例。超急性期及急性期脑梗死患侧ADC值较健侧对应区明显降低；从超急性期至慢性期ADC值逐渐升高，部分亚急性期患者梗塞区平均ADC值与健侧对应区几乎相同；慢性期平均ADC值与健侧对应区相比呈显著增高。在超、急性期脑梗塞中心平均ADC值明显低于周边区。除超急性期外，其余各期脑梗死患侧FA值均低于健侧对应区，慢性期脑梗死患侧较健侧对应区降低最为明显。DTT图可清楚显示脑白质纤维束走行，其中患侧白质纤维束较对侧无明显改变者13例，表现为稀疏、略减少者17例，表现为明显缺损中断者33例。 结论：1.PWI与DWI相结合，可以提示缺血半暗带的存在，指导临床治疗。2.病变区平均ADC值从急性到慢性期逐渐增加，慢性期显著高于健侧对应的区。超急性期及急性期患者病灶中心区的平均ADC值显著比周围区低。3.FA值及DTT图可以反映脑梗死灶脑白质纤维束的损伤情况。
[Abstract]:Purpose 1. To evaluate the value of combined use of DWI and PWI in cerebral infarction at different stages. To explore the ADC value of cerebral infarction in different periods and the changes of ADC value in different locations in acute phase. To investigate the changes of FA in cerebral infarction and its effect on white matter fiber bundle. Methods: from November 2012 to March 2014, 63 patients with cerebral infarction were collected, including 35 males and 28 females, with an average age of 61.3 years. They included 8 patients with acute cerebral infarction within 6 hours and 72 hours of acute cerebral infarction. There were 12 patients with subacute phase and 25 patients with chronic cerebral infarction more than 10 days after the onset of 6 hours or less. There were 18 patients with chronic cerebral infarction. All the patients underwent Mr conventional T _ 1 flaircontrast T _ 2 WI _ I _ T _ 2 flair contrast DWI DTI PWI scan. The ADCs of the affected and contralateral regions, the FA values of the affected and contralateral regions, the ADC values of the infarct center, edge and periphery of the patients in the acute phase were measured one by one, and the FA values of the corresponding areas of the affected and contralateral sides were measured one by one. The match between DWI and PWI and the damage of white matter fiber bundle on DTT were interpreted by two experienced radiologists. Results: in this study, there were 16 cases of PWIDWI with DWI 鈮
本文编号：2130715
[Abstract]:Purpose 1. To evaluate the value of combined use of DWI and PWI in cerebral infarction at different stages. To explore the ADC value of cerebral infarction in different periods and the changes of ADC value in different locations in acute phase. To investigate the changes of FA in cerebral infarction and its effect on white matter fiber bundle. Methods: from November 2012 to March 2014, 63 patients with cerebral infarction were collected, including 35 males and 28 females, with an average age of 61.3 years. They included 8 patients with acute cerebral infarction within 6 hours and 72 hours of acute cerebral infarction. There were 12 patients with subacute phase and 25 patients with chronic cerebral infarction more than 10 days after the onset of 6 hours or less. There were 18 patients with chronic cerebral infarction. All the patients underwent Mr conventional T _ 1 flaircontrast T _ 2 WI _ I _ T _ 2 flair contrast DWI DTI PWI scan. The ADCs of the affected and contralateral regions, the FA values of the affected and contralateral regions, the ADC values of the infarct center, edge and periphery of the patients in the acute phase were measured one by one, and the FA values of the corresponding areas of the affected and contralateral sides were measured one by one. The match between DWI and PWI and the damage of white matter fiber bundle on DTT were interpreted by two experienced radiologists. Results: in this study, there were 16 cases of PWIDWI with DWI 鈮
本文编号：2130715
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