脑老化过程中扣带回不同区域的rs-fMRI研究
发布时间：2018-07-22 12:26
【摘要】：目的:应用静息态功能磁共振成像(rs-f MRI)中的低频振幅(ALFF)及功能连接(FC)中的种子点相关分析方法,探讨中老年人与年轻人之间扣带回不同区域在静息态状态下大脑活动的差异。方法:将符合纳入标准的121名健康右利手志愿者,按年龄分为两组:年轻组60名,其中男23名,女37名,年龄范围22-31岁,平均年龄(26.2±1.9)岁;中老年组61名,其中男23名,女38名,年龄范围45-65岁,平均年龄(52.6±5.9)岁。将收集的被试者依次行静息态功能磁共振扫描,并将扣带回不同区域(AAL模板)的数据,用功能磁共振图像处理软件(DPARSFA、SPM、REST)进行预处理、ALFF、FC结果的计算以及统计学分析,经过Alphasim校正,最终将经过两样本T检验的结果叠加到rest软件自带的标准T2WI图像上进行显示,观察中老年人与年轻人静息态下扣带回不同区域的脑活动是否存在差异(P0.01),观察有统计学意义的活动团块的脑区定位、MNI坐标、团块的大小及其t值。结果:1 ALFF结果:1)静息状态下,中老年组较年轻组扣带回不同区域(AAL模板)并不是整体性增强或减弱,其内部部分团块活动有差别,并可得出有统计学意义团块的大小、MNI坐标及其t值;2)中老年组与年轻组比较,扣带回部分区域(31、32、35、36区)局部ALFF值减低,部分区域(33、34区)ALFF值未出现有统计学意义的变化。2 FC结果:分别以AAL模板中的扣带回不同区域(31-36区)为种子区域,利用功能连接的方法得出的中老年组较年轻组功能连接强度减弱的区域基本如下:1)左侧扣带回前部及其侧面环绕的脑回(31区):双侧小脑后叶、右侧海马旁回、左侧颞上回、右侧舌回、胼胝体右侧份、右侧岛叶、楔前叶;2)右侧扣带回前部及其侧面环绕的脑回(32区):左侧小脑后叶、右侧海马旁回、双侧颞上回、右侧岛叶、右侧额叶、楔前叶;3)左侧扣带回中部及其侧面环绕的脑回(33区):右侧小脑后叶、左侧颞上回、右侧小脑前叶、左侧海马旁回、右侧额下回、右侧枕下回、胼胝体、右侧额上回;4)右侧扣带回中部及其侧面环绕的脑回(34区):双侧颞上回、右侧海马旁回、胼胝体;5)左侧扣带回后部及其侧面环绕的脑回(35区):双侧海马旁回、胼胝体左侧份;6)右侧扣带回后部及其侧面环绕的脑回(36区):右侧颞上回、胼胝体。结论:1静息状态下,用ALFF的方法发现中老年组较年轻组(即随年龄增加)扣带回不同区域并不是整体性增强或减弱,扣带回前部及后部(31、32、35、36区)的局部神经元活动减弱,扣带回中部(33、34区)的神经元活性未见有统计学意义的变化,说明脑老化过程中,首先累及的是扣带回的前部及后部,中部累及较少;2静息状态下,用FC的方法可发现中老年组较年轻组扣带回不同区域连接强度下降的脑区不尽相同,有其各自连接强度减弱的脑区,这些脑区部分位于默认网络(DMN)区域内,说明脑老化过程中扣带回不同区域均不同程度累及默认网络,反映了脑老化对脑功能有负面影响。
[Abstract]:Objective: to investigate the difference of cerebral activity in different regions of cingulate gyrus between middle-aged, aged and young people in resting functional magnetic resonance imaging (rs-f) by using the methods of low-frequency amplitude (ALFF) and seed point correlation in functional junction (FC). Methods: 121 healthy right-handedness volunteers who met the inclusion criteria were divided into two groups according to their age: young group (n = 60), male (23), female (37), aged 22-31 years (mean age: 26.2 卤1.9), middle aged group (n = 61), male (n = 23) and female (n = 38). The age range was 45-65 years, the average age was (52.6 卤5.9) years. The collected subjects were scanned by resting functional magnetic resonance imaging (fMRI), and cingulate data were brought back to different regions (AAL template). The results of the FFFC were calculated and analyzed by the functional magnetic resonance image processing software (DPARSFAS) SPMREST, and corrected by Alphasim. Finally, the results of the two samples T-test are superimposed on the standard T2WI images of the rest software. To observe the difference of brain activity in different regions of cingulate gyrus between middle aged and young people (P0.01), to observe the MNI coordinates, the size and t value of cingulate gyrus. Results under the condition of rest, the cingulate region (AAL template) of the middle-aged and aged group was not enhanced or weakened, but the activity of some lumps in the middle and old group was different. It can be concluded that the MNI coordinate and t value of the mass are statistically significant. Compared with the young group, the ALFF values in the cingulate part of the middle and old age group (31n 32n 35N 36) are lower than those in the younger group. There was no significant change in ALFF value in some regions (33 / 34). 2 FC results: the different regions of cingulate gyrus (region 31-36) in AAL template were taken as seed regions, respectively. In the middle and old age group, the intensity of functional connection was decreased in the following areas: 1) the anterior cingulate gyrus and the lateral gyrus around the left cingulate gyrus (area 31): bilateral posterior cerebellar lobe, right parahippocampal gyrus, left superior temporal gyrus, bilateral posterior cerebellar lobe, right para-hippocampal gyrus, and left superior temporal gyrus. Right lingual gyrus, right part of corpus callosum, right insular lobe, right precuneial lobe (2) right anterior cingulate gyrus and its lateral gyrus (32 regions): left posterior cerebellar lobe, right parahippocampal gyrus, bilateral superior temporal gyrus, right insular lobe, right frontal lobe, right lateral cingulate gyrus, right superior temporal gyrus, right insular lobe, right frontal lobe. Left cingulate gyrus in the middle of the cingulate gyrus and its lateral circumference (area 33): right posterior lobe, left superior temporal gyrus, right anterior cerebellar lobe, left parahippocampal gyrus, right inferior frontal gyrus, right inferior occipital gyrus, corpus callosum, right inferior frontal gyrus, right inferior occipital gyrus, and corpus callosum. Right superior frontal gyrus 4) right middle cingulate gyrus and its lateral circumference gyrus (region 34): bilateral superior temporal gyrus, right para-hippocampal gyrus, corpus callosum 5) left posterior cingulate gyrus and its lateral circumferential gyrus (region 35): bilateral pariprahippocampal gyrus, The right gyrus around the posterior cingulate gyrus and its lateral region (area 36): right superior temporal gyrus, corpus callosum. Conclusion the ALFF method was used to find that different areas of cingulate gyrus were not enhanced or weakened in different regions of cingulate gyrus in the younger group (i.e. with age), but the local neuronal activity in the anterior and posterior cingulate gyrus (31 ~ 32n ~ (35) ~ (36) was decreased by using the ALFF method in the rest state of the cingulate gyrus. There was no significant change in neuronal activity in the middle cingulate gyrus (area 33), which indicated that the anterior and posterior cingulate gyrus were involved in the process of brain aging, and in the middle of the cingulate gyrus, there was no significant change in the neuronal activity in the middle part of the cingulate gyrus. By using FC method, it was found that the different regions of the cingulate gyrus decreased in different regions of the middle and old group, and some of these regions were located in the default network (DMN). The results showed that the default network was involved in different areas of cingulate gyrus during brain aging, which reflected the negative effect of brain aging on brain function.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R742
本文编号：2137462
[Abstract]:Objective: to investigate the difference of cerebral activity in different regions of cingulate gyrus between middle-aged, aged and young people in resting functional magnetic resonance imaging (rs-f) by using the methods of low-frequency amplitude (ALFF) and seed point correlation in functional junction (FC). Methods: 121 healthy right-handedness volunteers who met the inclusion criteria were divided into two groups according to their age: young group (n = 60), male (23), female (37), aged 22-31 years (mean age: 26.2 卤1.9), middle aged group (n = 61), male (n = 23) and female (n = 38). The age range was 45-65 years, the average age was (52.6 卤5.9) years. The collected subjects were scanned by resting functional magnetic resonance imaging (fMRI), and cingulate data were brought back to different regions (AAL template). The results of the FFFC were calculated and analyzed by the functional magnetic resonance image processing software (DPARSFAS) SPMREST, and corrected by Alphasim. Finally, the results of the two samples T-test are superimposed on the standard T2WI images of the rest software. To observe the difference of brain activity in different regions of cingulate gyrus between middle aged and young people (P0.01), to observe the MNI coordinates, the size and t value of cingulate gyrus. Results under the condition of rest, the cingulate region (AAL template) of the middle-aged and aged group was not enhanced or weakened, but the activity of some lumps in the middle and old group was different. It can be concluded that the MNI coordinate and t value of the mass are statistically significant. Compared with the young group, the ALFF values in the cingulate part of the middle and old age group (31n 32n 35N 36) are lower than those in the younger group. There was no significant change in ALFF value in some regions (33 / 34). 2 FC results: the different regions of cingulate gyrus (region 31-36) in AAL template were taken as seed regions, respectively. In the middle and old age group, the intensity of functional connection was decreased in the following areas: 1) the anterior cingulate gyrus and the lateral gyrus around the left cingulate gyrus (area 31): bilateral posterior cerebellar lobe, right parahippocampal gyrus, left superior temporal gyrus, bilateral posterior cerebellar lobe, right para-hippocampal gyrus, and left superior temporal gyrus. Right lingual gyrus, right part of corpus callosum, right insular lobe, right precuneial lobe (2) right anterior cingulate gyrus and its lateral gyrus (32 regions): left posterior cerebellar lobe, right parahippocampal gyrus, bilateral superior temporal gyrus, right insular lobe, right frontal lobe, right lateral cingulate gyrus, right superior temporal gyrus, right insular lobe, right frontal lobe. Left cingulate gyrus in the middle of the cingulate gyrus and its lateral circumference (area 33): right posterior lobe, left superior temporal gyrus, right anterior cerebellar lobe, left parahippocampal gyrus, right inferior frontal gyrus, right inferior occipital gyrus, corpus callosum, right inferior frontal gyrus, right inferior occipital gyrus, and corpus callosum. Right superior frontal gyrus 4) right middle cingulate gyrus and its lateral circumference gyrus (region 34): bilateral superior temporal gyrus, right para-hippocampal gyrus, corpus callosum 5) left posterior cingulate gyrus and its lateral circumferential gyrus (region 35): bilateral pariprahippocampal gyrus, The right gyrus around the posterior cingulate gyrus and its lateral region (area 36): right superior temporal gyrus, corpus callosum. Conclusion the ALFF method was used to find that different areas of cingulate gyrus were not enhanced or weakened in different regions of cingulate gyrus in the younger group (i.e. with age), but the local neuronal activity in the anterior and posterior cingulate gyrus (31 ~ 32n ~ (35) ~ (36) was decreased by using the ALFF method in the rest state of the cingulate gyrus. There was no significant change in neuronal activity in the middle cingulate gyrus (area 33), which indicated that the anterior and posterior cingulate gyrus were involved in the process of brain aging, and in the middle of the cingulate gyrus, there was no significant change in the neuronal activity in the middle part of the cingulate gyrus. By using FC method, it was found that the different regions of the cingulate gyrus decreased in different regions of the middle and old group, and some of these regions were located in the default network (DMN). The results showed that the default network was involved in different areas of cingulate gyrus during brain aging, which reflected the negative effect of brain aging on brain function.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R742
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