低海拔正常成人移居高海拔地区2年后脑的适应性变化

发布时间：2018-07-29 16:37

【摘要】：目的观察低海拔正常成人移居高海拔地区2年后脑的适应性变化。方法选择初入西宁地区1周内的19例来自低海拔的正常成人,接受静息态功能磁共振全脑扫描,移居2年后再次接受该检查,应用基于体素形态学测量技术(VBM)、功能磁共振中低频振幅(ALFF)和局部一致性(ReHo)的方法对其移居前后脑结构及功能进行分析。结果低海拔正常成人移居高海拔地区2年后较移居前自身脑结构比较未见显著性变化。与移居前相比,移居后左侧眶内额上回、左侧脑岛、左侧顶下缘角回脑区ReHo增加(P均0.05),右侧楔叶、右侧顶上回、右侧梭状回脑区ReHo减低(P均0.05),左侧额中回、左侧背外侧额上回、左侧脑岛、左侧前扣带回和旁扣带脑回脑区ALFF增加(P均0.01),右侧舌回脑区ALFF减低(P0.01)。结论低海拔正常成人移居高海拔地区2年后脑功能发生适应性改变,这可能是适应长期低氧环境变化的结果。
[Abstract]:Objective to observe the changes of brain adaptability after 2 years of migration in low altitude normal adults. Methods A total of 19 normal adults from low altitude were enrolled in Xining area within 1 week and underwent resting functional magnetic resonance imaging (fMRI). After 2 years of migration, they were examined again. The low frequency amplitude (ALFF) and local consistent (ReHo) were used to analyze the brain structure and function in (VBM), functional magnetic resonance based on voxel morphology measurement before and after migration. Results there was no significant change in the brain structure of normal adults at low altitude after 2 years of migration. Compared with pre-emigration, the ReHo of left superior orbital gyrus, left island, left inferior parietal angle gyrus increased (P 0.05), ReHo of right cuneate lobe, right superior parietal gyrus, right fusiform gyrus decreased (P 0.05), left middle frontal gyrus, left dorsolateral superior frontal gyrus, left middle frontal gyrus and left dorsolateral superior frontal gyrus. ALFF increased in left cerebral island, left anterior cingulate gyrus and paracentellar gyrus (P0.01), and ALFF in right lingual gyrus decreased (P0.01). Conclusion the adaptive changes of brain function occurred after 2 years of migration to high altitude in normal adults at low altitude, which may be the result of adaptation to long-term hypoxic environment.
【作者单位】：青海大学附属医院;
【基金】：国家自然科学基金资助项目(81060177) 青海省科技厅科技计划项目(2017-SF-158);青海省科技厅国际合作项目(2012-H-807)
【分类号】：R445.2

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