20418例CT检查非离子型碘对比剂不良反应分析

发布时间：2018-08-01 11:55

【摘要】：目的分析CT检查注射非离子型碘对比剂用药信息与不良反应发生特点,为临床CT检查选择用药、患者告知、针对性各类不良反应处置提供实证依据和参考借鉴。资料与方法回顾性分析2013年7月—2016年9月甘肃省人民医院放射科20 418例行CT检查应用非离子型碘对比剂病例的一般资料、用药类型与名称、不良反应发生时间与症状表现等。结果本组观察对象中,男11 679例、女8739例,年龄3~93岁,平均(52.1±13.2)岁。非离子型碘对比剂各类不良反应发生率为0.4%,次高渗、等渗碘对比剂不良反应发生率分别为0.47%、0.27%。81例不良反应中,急性91.3%,其中88.9%发生在注射后15 min内;迟发性8.7%。轻中度97.6%,重度2.4%。引起不良反应的碘对比剂次高渗74.0%,等渗26.0%;迟发不良反应主要为等渗对比剂所致,表现为轻中度。不良反应症状表现频次依次为皮肤、消化道、中枢神经系统、呼吸系统、循环系统症状。结论碘对比剂所致不良反应以急性、轻中度为主,检查前应向患者或家属详尽告知。碘对比剂重度不良反应发生迅速,多系统同时受累,现场有效处置极为关键;等渗碘对比剂所致迟发反应需引起重视。
[Abstract]:Objective to analyze the information of injection of Nonionic iodine contrast agent and the characteristics of adverse drug reactions in CT examination, and to provide empirical basis and reference for clinical CT examination to choose medication, inform patients and deal with all kinds of adverse reactions. Materials and methods from July 2013 to September 2016, the general data, drug types and names, the occurrence time and symptom of adverse reactions of 20 418 patients with Nonionic iodine contrast agent were analyzed retrospectively in Department of Radiology of Gansu Provincial people's Hospital. Results there were 11 679 males and 8739 females with a mean age of (52. 1 卤13. 2) years (393 years). The incidence of various adverse reactions of Nonionic iodine contrast agent was 0.4, the incidence of secondary hyperosmotic and isoosmotic iodine contrast agent was 0.470.27.81 cases, acute 91.3%, of which 88.9% occurred within 15 min after injection, and delayed 8.7. Mild to moderate 97.6, heavy 2.4. The secondary hypertonic iodine contrast agent caused adverse reaction was 74.0 and isosmotic 26.0, and the delayed adverse reaction was mainly caused by isosmotic contrast agent, which showed mild to moderate. The symptoms of adverse reactions were skin, digestive tract, central nervous system, respiratory system and circulatory system. Conclusion the adverse reactions caused by iodine contrast agent are mainly acute, mild and moderate. The severe adverse reactions of iodine contrast agents occur rapidly, and many systems are simultaneously involved, so it is very important to deal with them effectively on the spot, and the late reaction caused by isotonic iodine contrast agents should be paid more attention to.
【作者单位】：甘肃省人民医院放射科;
【分类号】：R816

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