fMRI分析非临床抑郁大学生杏仁核及海马静息态功能连接的改变
发布时间：2018-08-02 18:52
【摘要】：目的分析非临床抑郁症状(nCDSs)被试杏仁核及海马静息态功能连接的特征。方法采用贝克抑郁量表(BDI)对1105名大学生进行抑郁症状评估,对其中17例符合nCDSs的被试(nCDSs组)及20名对照组被试进行静息态fMRI检查。以双侧杏仁核及海马为种子点,分别对全脑进行基于体素的rsFC分析,比较两组间的rsFC差异,并与nCDSs者的BDI评分进行相关分析。结果与对照组比较,nCDSs组以双侧杏仁核为种子点,右侧眶额叶内侧面rsFC均增强;以左侧海马为种子点,右侧枕叶舌回、双侧额叶直回及左侧楔前叶rsFC增强;以右侧海马为种子点,右侧小脑后叶、右侧枕叶舌回、双侧额叶直回、左侧楔前叶及左侧中央旁小叶rsFC增强。nCDSs被试双侧杏仁核及海马rsFC改变与BDI评分无相关性(P0.05)。结论 nCDSs被试杏仁核及海马的rsFC存在异常,可能在nCDSs的病理机制中发挥重要作用。
[Abstract]:Objective to analyze the characteristics of resting functional connections in the amygdala and hippocampus of (nCDSs) subjects with non-clinical depressive symptoms. Methods 1105 college students were assessed with Beck Depression scale (BDI) and 17 subjects (nCDSs group) and 20 normal subjects (control group) were examined by resting fMRI. Using bilateral amygdala and hippocampus as seed points, the whole brain was analyzed by voxel based rsFC analysis, and the difference of rsFC between the two groups was compared, and the correlation analysis was made between the two groups and the BDI score of nCDSs patients. Results compared with the control group, the bilateral amygdaloid nucleus as seed point and the medial side of the right orbital frontal lobe increased in the nCDSs group, the left hippocampus as the seed point, the right occipital lobe as the seed point, the bilateral frontal gyrus as the straight gyrus and the left cuneate lobe as the seed point, the right hippocampus as the seed point, and the right hippocampus as the seed point. Right posterior cerebellar lobe, right occipital lobe lingual gyrus, bilateral frontal lobe straight gyrus, left prewedge lobe and left paracentral lobule rsFC enhanced. NCDSs showed no correlation with BDI score in bilateral amygdaloid nucleus and hippocampus (P0.05). Conclusion the abnormality of rsFC in amygdala and hippocampus in nCDSs subjects may play an important role in the pathological mechanism of nCDSs.
【作者单位】： 广州医科大学附属广州市第一人民医院放射科;广州医科大学管理学院;
【基金】：广州市科技计划项目(2014J4100071)
【分类号】：R749.4;R445.2
[Abstract]:Objective to analyze the characteristics of resting functional connections in the amygdala and hippocampus of (nCDSs) subjects with non-clinical depressive symptoms. Methods 1105 college students were assessed with Beck Depression scale (BDI) and 17 subjects (nCDSs group) and 20 normal subjects (control group) were examined by resting fMRI. Using bilateral amygdala and hippocampus as seed points, the whole brain was analyzed by voxel based rsFC analysis, and the difference of rsFC between the two groups was compared, and the correlation analysis was made between the two groups and the BDI score of nCDSs patients. Results compared with the control group, the bilateral amygdaloid nucleus as seed point and the medial side of the right orbital frontal lobe increased in the nCDSs group, the left hippocampus as the seed point, the right occipital lobe as the seed point, the bilateral frontal gyrus as the straight gyrus and the left cuneate lobe as the seed point, the right hippocampus as the seed point, and the right hippocampus as the seed point. Right posterior cerebellar lobe, right occipital lobe lingual gyrus, bilateral frontal lobe straight gyrus, left prewedge lobe and left paracentral lobule rsFC enhanced. NCDSs showed no correlation with BDI score in bilateral amygdaloid nucleus and hippocampus (P0.05). Conclusion the abnormality of rsFC in amygdala and hippocampus in nCDSs subjects may play an important role in the pathological mechanism of nCDSs.
【作者单位】： 广州医科大学附属广州市第一人民医院放射科;广州医科大学管理学院;
【基金】：广州市科技计划项目(2014J4100071)
【分类号】：R749.4;R445.2
【参考文献】
相关期刊论文 前2条
1 王亮;于春水;;静息状态脑功能连接磁共振成像的分析方法及应用[J];中国医学影像技术;2008年08期
2 周敏;胡治国;;抑郁症患者自我相关加工的fMRI研究现状[J];中国医学影像技术;2014年01期
【共引文献】
相关期刊论文 前10条
1 孙aS，
本文编号：2160385
本文链接：https://www.wllwen.com/yixuelunwen/fangshe/2160385.html
