斑点追踪技术在评价犬心肌不同顿抑状态力学特征中的应用

发布时间：2018-08-09 09:15

【摘要】：目的应用斑点追踪技术评价犬不同顿抑状态心肌与正常心肌的力学参数差异及动态变化过程。方法制作冠状动脉左前降支阻断后再灌注犬心肌顿抑模型,分为短顿抑组(阻断15 min)、长顿抑组(阻断45min)和假手术组(不阻断)。分别于阻断前、再灌注即刻、再灌注10、30、60、90、120 min对心肌的径向应变、环向应变参数进行比较。结果再灌注即刻,长顿抑组缺血心肌的径向应变、环向应变(绝对值)低于结扎前及假手术组(P0.01),且低于短顿抑组缺血心肌(P0.05),短顿抑组缺血心肌的径向应变低于结扎前及假手术组(P0.01),短顿抑组缺血心肌的环向应变(绝对值)低于结扎前及假手术组(P0.05);至再灌注30 min,上述指标进一步降低。再灌注60、90、120 min时,长顿抑组和短顿抑组缺血心肌径向应变及环向应变(绝对值)有所恢复,但仍低于基础状态和假手术组(P0.05,P0.01)。再灌注120 min时长顿抑组缺血心肌径向应变低于短顿抑组(P0.05)。结论斑点追踪技术可以定量评估不同顿抑状态的心肌力学差异及其动态变化,能为临床治疗和疗效评价提供有力证据。
[Abstract]:Objective to evaluate the difference of mechanical parameters and dynamic changes between canine myocardium and normal myocardium by speckle tracing technique. Methods the model of myocardial stunning after left anterior descending coronary artery occlusion was established in dogs. The model was divided into two groups: short occlusion group (15 min), occlusion group) and sham operation group (45min group). The radial and circumferential strain parameters of myocardium were compared before and immediately after reperfusion for 10 ~ 30 ~ 60,90120 min. Results immediately after reperfusion, the radial strain of ischemic myocardium was observed in the long stuffing group. The circumferential strain (absolute value) was lower than that before ligation and sham-operation group (P0.01), and lower than that of ischemic myocardium (P0.05). The radial strain of ischemic myocardium was lower than that of pre-ligation and sham-operation group (P0.01). The absolute value was lower than that before ligation and sham-operation group (P0.05), and the above indexes were further decreased at 30 min after reperfusion. The radial strain and circumferential strain (absolute value) of ischemic myocardium in long and short stunning groups recovered at 60,90120 min after reperfusion, but they were still lower than those in basic state and sham-operation group (P0.05, P0.01). After 120 min reperfusion, the radial strain of ischemic myocardium was lower in the prolonged stunning group than in the short one group (P0.05). Conclusion Dot tracing technique can be used to quantitatively evaluate the dynamic changes of myocardial mechanics in different stunning states and can provide strong evidence for clinical treatment and evaluation of curative effect.
【作者单位】：广东省中医院超声科;广东省中医院心胸外科;广东省中医院消化内科;
【基金】：广东省自然科学基金资助项目(编号:S2011010003936)
【分类号】：R542.2;R445.1

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