妊高征患者分娩后血管内皮功能的超声序贯研究

发布时间：2018-08-19 14:44

【摘要】：目的探讨妊娠高血压综合征(PIH)患者分娩后,不同时期是否存在内皮依赖性血管舒张功能受损。方法 146例PIH患者分娩后1、6周及24周行高频超声检测右侧肱动脉内皮依赖性血管舒张功能,对照组为125例正常妊娠分娩后女性。测量静息状态下右侧肱动脉内径(D1)、血流量(Q1)及反应性充血后内径(D2)、血流量(Q2);计算内径变化率(△D%)及血流量变化率(△Q%)。结果分娩后1、6周及24周PIH患者的△D%及△Q%均低于对照组(P0.001);PIH患者分娩后不同时期△D%及△Q%比较,差异无统计学意义(P0.05);分娩后不同时期PIH患者组内各亚组间△D%及△Q%两两比较,重度子痫前期患者均低于妊娠期高血压和轻度子痫前期患者(P0.05)。结论 PIH患者分娩后存在内皮依赖性血管舒张功能受损,至少持续至分娩后24周时尚无明显恢复和改善,且重度子痫前期患者血管内皮功能受损程度更重。
[Abstract]:Objective to investigate whether endothelium-dependent vasodilation is impaired in patients with pregnancy induced hypertension (PIH) after delivery. Methods the endothelium-dependent vasodilation function of the right brachial artery was detected by high frequency ultrasound in 146 patients with PIH at 6 and 24 weeks postpartum, while that in the control group was 125 normal postpartum women. The diameter of right brachial artery (D1), blood flow (Q1), the diameter of reactive hyperemia (D2) and blood flow (Q2) were measured, and the change rate of internal diameter (D%) and blood flow rate (Q%) were calculated. Results the D% and Q% of patients with PIH at 6 and 24 weeks after delivery were lower than those in the control group (P0.001). The difference was not statistically significant (P0.05); D% and Q% were significantly lower in patients with severe preeclampsia than in patients with hypertension and mild preeclampsia at different stages of labor (P0.05). Conclusion Endothelium-dependent vasodilation function is impaired after delivery in PIH patients, and no significant recovery or improvement is found until 24 weeks after delivery, and the degree of impaired vascular endothelial function in patients with severe preeclampsia is more serious than that in patients with severe preeclampsia.
【作者单位】：海南医学院第一附属医院超声科;
【基金】：2014海南省卫生计生委普通科研项目(No.14A210270) 2014年海南省自然科学基金(No.814358)
【分类号】：R445.1;R714

【相似文献】