大脑胶质瘤交叉性小脑神经机能联系不能的MR动脉自旋标记灌注成像

发布时间：2018-08-20 20:01

【摘要】：目的采用MR三维动脉自旋标记(3D ASL)灌注成像技术探讨大脑胶质瘤患者交叉性小脑神经机能联系不能(CCD)现象。方法回顾性分析31名大脑胶质瘤患者和31名正常人的MR资料,采用3D ASL灌注成像技术测量脑组织的脑血流量(CBF),计算并比较患者小脑半球CBF值不对称指数(AI)改变。分析小脑半球AI与大脑半球肿瘤区域AI、肿瘤级别、病变体积的关系。结果大脑胶质瘤患者肿瘤对侧小脑半球CBF值较同侧小脑半球降低(t=5.04,P0.01),胶质瘤患者小脑半球AI(AI_(小脑))较正常人增高(t=4.13,P0.01),高级别与低级别胶质瘤间AI_(小脑)的差异无统计学意义(t=1.31,P0.05)。患者AI_(小脑)与大脑肿瘤区域AI(AI_(肿瘤):r=-0.28;AI_(肿瘤实质):r=-0.24;AI_(肿瘤加水肿):r=-0.19)、病变体积(r=0.18)均无相关性(P均0.05)。结论大脑胶质瘤可出现CCD现象,3D ASL灌注成像可无创定量评估小脑半球低灌注程度,但CCD现象与肿瘤的级别、病变范围及大脑半球AI无明显相关。
[Abstract]:Objective to investigate the phenomenon of intersecting cerebellar nerve dysfunction (CCD) in patients with cerebral glioma by Mr three-dimensional arterial spin labeling (3D ASL) perfusion imaging. Methods the MRI data of 31 patients with glioma and 31 normal controls were analyzed retrospectively. The cerebral blood flow (CBF),) of brain tissue was measured by 3D ASL perfusion imaging and the CBF asymmetry index (AI) of cerebellar hemisphere was compared. To analyze the relationship between AI in cerebellar hemisphere and AI1, tumor grade and lesion volume in cerebral hemispheres. Results the CBF value of the contralateral cerebellar hemisphere in glioma patients was lower than that in the ipsilateral cerebellar hemisphere (t0. 04 卤P0. 01), and the AI in the cerebellar hemisphere of glioma patients was higher than that in the normal controls (t 4. 13, P 0. 01). There was no significant difference between the high grade gliomas and the low grade gliomas (t 1. 31 P 0. 05). There was no correlation between AI in the cerebellum and AI (AI) in the tumor region of the cerebellum (AI): r-0.28% (tumor parenchyma): r-0.24% AI-0.19 (tumor with edema), and the volume of lesion (rn 0.18) was not correlated (P 0.05). Conclusion CCD can occur in gliomas. 3D ASL perfusion imaging can be used to quantitatively evaluate the degree of hypoperfusion in cerebellar hemisphere, but there is no significant correlation between CCD phenomenon and tumor grade, lesion extent and AI in cerebral hemisphere.
【作者单位】：徐州医科大学医学影像学院;南京总医院医学影像科;
【基金】：国家自然科学基金(81530054)
【分类号】：R739.41;R445.2

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