基于神经影像学脑网络分析方法的抑郁症患者的脑功能评估研究

发布时间：2018-08-26 20:55

【摘要】：背景:SAPHO(synovitis-acne-pustulosis-hyperostosis-osteitis,SAPHO)综合征是一种罕见的疾病,目前尚无专门关于SAPHO综合征合并抑郁症的报道。我们的研究旨在通过脑神经网络分析方法揭示SAPHO患者存在抑郁症。材料与方法:连续招募28名SAPHO患者和15位年龄和性别匹配的正常对照进行精神评估和静息态功能磁共振成像(Resting state functional magnetic resonance imaging,rs-fMRI)扫描。通过精神评估将这批患者分为SAPHO抑郁组和SAPHO非抑郁组。结果:13例SAPHO综合征患者被诊断为抑郁症,被分在SAPHO抑郁组,另外15例SAPHO综合征患者被归为SAPHO非抑郁组。局部脑活动研究表明,与SAPHO非抑郁组相比,SAPHO抑郁组双侧腹外侧及右侧背外侧前额叶皮层低频振幅(Amplitude of low-frequency fluctuation,ALFF)值减低,双侧颞中回ALFF值增高。功能连接(Functional connectivity,FC)研究表明,相较SAPHO非抑郁组,SAPHO抑郁组在默认网络前部(双侧额下回皮质,前扣带皮质和岛叶皮质)FC显著增加,默认网络后部的区域(左枕中回皮质)FC显著减低。此外,相关性分析显示ALFF和FC值均与SAPHO患者的抑郁评分显著相关。结论:神经影像学脑网络分析方法揭示部分SAPHO综合征患者伴有抑郁症。rs-fMRI有助于人们理解SAPHO综合征合并抑郁症的潜在神经生物学机制,这有望成为监测SAPHO综合征合并抑郁症的影像学指标。
[Abstract]:Background: synovitis-acne-pustulosis-hyperostosis-osteitis,SAPHO syndrome is a rare disease and there are no reports of SAPHO syndrome with depression. Our study was designed to reveal depression in patients with SAPHO by neural network analysis. Materials and methods: 28 SAPHO patients and 15 age-matched normal controls were recruited for mental evaluation and resting functional magnetic resonance imaging (Resting state functional magnetic resonance imaging,rs-fMRI) scans. The patients were divided into SAPHO depression group and SAPHO non-depression group. Results 13 patients with SAPHO's syndrome were diagnosed as depression and were divided into SAPHO depression group and 15 SAPHO syndrome patients were classified as SAPHO non-depression group. Local brain activity study showed that the low frequency amplitude (Amplitude of low-frequency fluctuation,ALFF (Amplitude of low-frequency fluctuation,ALFF) of bilateral ventrolateral and right dorsolateral prefrontal cortex was decreased and the ALFF value of bilateral middle temporal gyrus increased in the sappo depression group compared with the non-depression group of SAPHO. The functional junction (Functional connectivity,FC) study showed that the FC in the anterior part of the default network (bilateral inferior frontal cortex, anterior cingulate cortex and insular lobe cortex) was significantly higher than that in the SAPHO non-depression group, and the FC in the posterior part of the default network (left occipital middle gyrus) was significantly lower. In addition, correlation analysis showed that both ALFF and FC were significantly correlated with depression scores in SAPHO patients. Conclusion: brain network analysis of neuroimaging revealed that partial SAPHO syndrome patients with depression. Rs-fMRI is helpful to understand the underlying neurobiological mechanism of SAPHO syndrome with depression. This is expected to be an imaging marker for monitoring SAPHO syndrome with depression.
【学位授予单位】：北京协和医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749.4;R445.2

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