DCE-MRI鉴别肝脏占位性病变的研究

发布时间：2018-09-03 20:26

【摘要】：目的:研究DCE-MRI定量参数在肝脏占位性病变中的诊断价值。方法:采用MRI扫描仪对55例肝脏占位患者进行定量动态增强扫描,分别测量定量血流动力学参数:容量转运常数(Ktrans)、血管外细胞外容积分数(Ve)和速率常数(Kep),血管瘤组、肝癌组及转移瘤组间定量参数行单因素方差分析及LSD法两两比较;对3组组间绘制受试者特性(ROC)曲线。结果:血管瘤与肝癌、血管瘤与转移瘤、肝癌与转移瘤组之间Ktrans及Ve值差异均有统计学意义(P0.05);血管瘤与肝癌、肝癌与转移瘤组间Kep值差异有统计学意义(P0.05);血管瘤与转移瘤组间Kep差异无统计学意义(P0.05)。以最大约登指数得到最佳诊断切点值,则3者判断及鉴别血管瘤和肝癌的敏感度分别为88.2%、82.4%、94.1%,特异度分别为81.8%、59.1%、81.8%;鉴别血管瘤与转移瘤的敏感度分别为68.2%、68.2%、50.0%,特异度分别为81.2%、87.5%、81.2%;鉴别肝癌与转移瘤的敏感度分别为100.0%、82.4%、100.0%,特异度分别为93.7%、93.7%、93.7%。结论:DCE-MRI定量血流动力学参数Ktrans、Kep对肝脏占位性病变的鉴别诊断具有很高的价值。
[Abstract]:Objective: to study the diagnostic value of DCE-MRI quantitative parameters in hepatic space-occupying lesions. Methods: a total of 55 patients with hepatic space occupying were examined with MRI scanner. The quantitative hemodynamic parameters were measured: volume transfer constant (Ktrans),) extracellular volume fraction (Ve) and rate constant (Kep), hemangioma group. Single factor analysis of variance (ANOVA) and LSD method were used to compare the quantitative parameters between HCC group and metastatic tumor group, and the (ROC) curves of the three groups were drawn. Results: there were significant differences in Ktrans and Ve between hemangioma and hepatoma, hemangioma and metastasis, hepatoma and metastasis (P0.05). There was significant difference in Kep between HCC and metastatic tumor group (P0.05), but there was no significant difference in Kep between hemangioma group and metastatic tumor group (P0.05). The best diagnostic tangent value is obtained from the maximum Jordan index. The sensitivity of judging and differentiating hemangioma and liver cancer was 88.20.82.4and 94.1, and the specificity was 81.80.The sensitivity of differentiating hemangioma from metastatic tumor was 68.2 and 68.2, and the specificity was 81.27.55.The sensitivity of differentiating liver cancer from metastatic tumor was 100.082.40.The specificity was 93.793. 70.The sensitivity of differentiating liver cancer and metastatic tumor was 100.082.4and 100.0.The specificity was 93.793. 70.The sensitivity of differentiating hemangioma and metastatic tumor was 82.40.The specificity was 93.70.The sensitivity of differentiating hemangioma from metastatic tumor was 81.27.50.The sensitivity of differentiating liver cancer and metastatic tumor was 100.082.4and 100.0.The specificity was 93.793. Conclusion the quantitative hemodynamic parameter Ktrans,Kep is of great value in the differential diagnosis of hepatic space-occupying lesions.
【作者单位】：新疆医科大学第二附属医院影像中心;新疆医科大学第一附属医院影像中心;
【基金】：新疆维吾尔自治区科技计划项目,项目编号(201333104)
【分类号】：R735.7;R445.2

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