Gd-EOB-DTPA增强磁共振对胰腺癌肝转移诊断效果的初步研究
发布时间：2018-09-06 19:56
【摘要】：目的：研究Gd-EOB-DTPA对胰腺癌肝转移灶的显示能力,以及转移灶、化疗对肝实质整体显示情况的影响,确定病灶最佳观察时间,提高检出率。方法：收集分析24例胰腺癌患者的肝脏Gd-EOB-DTPA增强MRI图像。依据是否伴有肝转移,是否进行过化疗对患者进行分别分组。分析所有研究对象的肝实质SNR情况和转移瘤结节的SNR、CNR、CER隋况。比较各组间肝实质SNR是否存在差异,结节不同期相的SNR、CER是否有差异,分析转移对肝实质信号的影响,化疗对肝实质信号的影响。绘制时间-SNR曲线、时间-CNR曲线和时间-CER曲线,分析病灶信号改变的情况。结果：①胰腺癌肝转移瘤在延迟15分钟的Gd-EOB-DTPA增强磁共振上具有最佳的信号差别。 ②无论是否伴有转移瘤,在延迟15分钟时肝实质图像质量最佳,但两组肝实质的各期SNR差值不具有统计学意义(P0.05)。③转移瘤阴性的胰腺癌患者,无论是否进行化疗,在延迟15分钟时肝实质图像质量最佳,但两组肝实质的各期SNR差值不具有统计学意义(P0.05)。④转移瘤非阴性的胰腺癌患者,未化疗组在延迟15分钟时肝实质图像质量最佳,化疗组最佳观察时间在15分钟之后。但两组肝实质的各期SNR差值不具有统计学意义(P0.05)。⑤扫描序列先后顺序的设定可对结节CER的计算产生影响。结论：胰腺癌肝转移瘤在延迟15分钟的Gd-EOB-DTPA增强磁共振上具有最佳的信号差别,此时转移灶能和肝实质形成最大对比,有利于病灶的发现和检出。胰腺癌患者无论是否伴有肝转移,无论是否进行过化疗,均在延迟15分钟时最适合观察肝实质情况。
[Abstract]:Aim: to study the display ability of Gd-EOB-DTPA in hepatic metastases of pancreatic cancer and the effect of chemotherapy and chemotherapy on the overall display of hepatic parenchyma, to determine the best observation time and to improve the detection rate. Methods: Gd-EOB-DTPA enhanced MRI images of liver were collected and analyzed in 24 patients with pancreatic cancer. Patients were divided into groups according to whether they had liver metastasis and whether they had been treated with chemotherapy. The SNR of liver parenchyma and the SNR,CNR,CER sui condition of metastatic tumor were analyzed in all subjects. The effects of metastasis on hepatic parenchyma signal and the effect of chemotherapy on hepatic parenchyma signal were analyzed. Time-SNR curve, time-CNR curve and time-CER curve were plotted to analyze the change of lesion signal. Results there was the best signal difference in Gd-EOB-DTPA enhanced MRI with or without 15 minutes delay of 15 minutes in metastatic tumor of pancreatic carcinoma. 2 the liver parenchyma image quality was the best in 15 minutes delay. However, the difference of SNR in each stage of liver parenchyma between the two groups was not statistically significant (P0.05). 3. The liver parenchyma image quality was the best in patients with pancreatic cancer with negative metastasis, whether or not chemotherapy was performed. However, the difference of SNR in each stage of liver parenchyma between the two groups was not statistically significant (P0.05). 4. 4. 4. The liver parenchyma image quality was the best in the non-chemotherapy group at the delay of 15 minutes, and the best observation time in the chemotherapy group was after 15 minutes. However, the difference of SNR in each phase of liver parenchyma between the two groups was not statistically significant (P0.05). 5. The sequence of scanning sequence could affect the calculation of nodular CER. Conclusion: hepatic metastases of pancreatic cancer have the best signal difference on Gd-EOB-DTPA enhanced MRI with a delay of 15 minutes. At this time, the metastatic focus can be compared with the hepatic parenchyma, which is beneficial to the detection and detection of the lesions. The hepatic parenchyma was best observed in pancreatic cancer patients with or without hepatic metastasis and with or without chemotherapy.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R445.2;R735.9
本文编号：2227384
[Abstract]:Aim: to study the display ability of Gd-EOB-DTPA in hepatic metastases of pancreatic cancer and the effect of chemotherapy and chemotherapy on the overall display of hepatic parenchyma, to determine the best observation time and to improve the detection rate. Methods: Gd-EOB-DTPA enhanced MRI images of liver were collected and analyzed in 24 patients with pancreatic cancer. Patients were divided into groups according to whether they had liver metastasis and whether they had been treated with chemotherapy. The SNR of liver parenchyma and the SNR,CNR,CER sui condition of metastatic tumor were analyzed in all subjects. The effects of metastasis on hepatic parenchyma signal and the effect of chemotherapy on hepatic parenchyma signal were analyzed. Time-SNR curve, time-CNR curve and time-CER curve were plotted to analyze the change of lesion signal. Results there was the best signal difference in Gd-EOB-DTPA enhanced MRI with or without 15 minutes delay of 15 minutes in metastatic tumor of pancreatic carcinoma. 2 the liver parenchyma image quality was the best in 15 minutes delay. However, the difference of SNR in each stage of liver parenchyma between the two groups was not statistically significant (P0.05). 3. The liver parenchyma image quality was the best in patients with pancreatic cancer with negative metastasis, whether or not chemotherapy was performed. However, the difference of SNR in each stage of liver parenchyma between the two groups was not statistically significant (P0.05). 4. 4. 4. The liver parenchyma image quality was the best in the non-chemotherapy group at the delay of 15 minutes, and the best observation time in the chemotherapy group was after 15 minutes. However, the difference of SNR in each phase of liver parenchyma between the two groups was not statistically significant (P0.05). 5. The sequence of scanning sequence could affect the calculation of nodular CER. Conclusion: hepatic metastases of pancreatic cancer have the best signal difference on Gd-EOB-DTPA enhanced MRI with a delay of 15 minutes. At this time, the metastatic focus can be compared with the hepatic parenchyma, which is beneficial to the detection and detection of the lesions. The hepatic parenchyma was best observed in pancreatic cancer patients with or without hepatic metastasis and with or without chemotherapy.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R445.2;R735.9
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