健康志愿者肾脏ADC值测量及其影响因素的初步研究
发布时间：2018-09-11 16:29
【摘要】：目的：探讨年龄和性别因素对健康志愿者肾脏ADC值的影响。材料与方法：2012年6月至2013年8月共100名健康志愿者纳入本研究（其中男女各50名，年龄18-69岁，平均44岁），所有志愿者肾功能正常、没有泌尿系统疾病和高血压等基础病。根据年龄分为5个组（18-29岁，30-39岁，40-49岁，50-59岁和60-69岁），每组各20名，在3.0T磁共振扫描仪上行肾脏MR常规平扫和RT-DWI成像（b值采用800s/mm2），测量肾实质ADC值并进行统计学分析。结果：1、5个年龄段肾实质ADC值依次为(2.066±0.099)×10-3mm2/s、(2.059±0.124)×10-3mm2/s、(2.034±0.103)×10-3mm2/s、(1.985±0.172)×10-3mm2/s、(1.943±0.125)×10-3mm2/s，各组间具有统计学差异(F=3.375，P0.05)。2、5个不同年龄段男性肾实质ADC值依次为(2.087±0.094)×10-3mm2/s、(2.086±0.146)×10-3mm2/s、(2.042±0.117)×10-3mm2/s、(2.041±0.205)×10-3mm2/s、(1.979±0.122)×10-3mm2/s；女性肾实质ADC值依次为(2.060±0.126)×10-3mm2/s、(2.031±0.097)×10-3mm2/s、(2.026±0.092)×10-3mm2/s、(1.929±0.115)×10-3mm2/s、(1.907±0.124)×10-3mm2/s。5个不同年龄组男性平均ADC值均大于女性，差异没有统计学意义（P0.05）。结论：健康志愿者肾脏ADC值受年龄和性别的影响：伴随年龄的增长，健康志愿者肾实质ADC值呈减小的趋势；同一年龄段男性和女性ADC值无显著差别。因此，DWI成像在临床应用时应考虑到年龄和性别因素对ADC值的影响。 第二部分健康志愿者肾脏1.5T和3.0T磁共振扩散加权成像的对比研究 目的：探讨不同场强（1.5T和3.0T）对ADC值测量和图像质量的影响。材料与方法：2012年6月至2013年12月共150名健康志愿者（其中男女各75名，年龄18-73岁，平均38岁）纳入本研究，根据年龄分为5个组（18-29岁，30-39岁，40-49岁，50-59岁和60-69岁），每组各30名，同一志愿者分别在 1.5T与3.0T磁共振扫描仪上进行肾脏FB-DWI和RT-DWI成像（b值均采用800s/mm2）。通过配对t检验比较两种场强DWI图像的信噪比（SNR），通过单因素方差分析进行比较肾脏不同部位（上、中和下部）ADC值差异，通过Pearson相关分析比较不同场强ADC值测量的一致性。结果：1、FB-DWI图像3.0T和1.5T MR的SNR分别为（66.500±14.776）、（51.570±8.578），差异具有统计学意义（P0.05）；RT-DWI图像3.0T和1.5T MR的SNR分别为（66.611±20.748）、（44.989±11.461），差异具有统计学意义（P0.05）。 2、1.5T MR肾脏上部、中部和下部的ADC值分别为(1.998±0.102)×10-3mm2/s、(2.157±0.166)×10-3mm2/s、(2.050±0.183)×10-3mm2/s，3.0T MR肾脏上部、中部和下部的ADC值分别为(2.042±0.094)×10-3mm2/s、(2.073±0.147)×10-3mm2/s、(1.947±0.086)×10-3mm2/s，同一场强肾脏三个部位的ADC值无统计学差异(1.5T：F=2.485，P0.05；3.0T：F=3.107，P0.05)，肾脏同一部位在不同场强下ADC值无统计学差异（P0.05）。3、1.5T MR5个年龄段肾实质ADC值依次为(2.165±0.162)×10-3mm2/s、(2.145±0.157)×10-3mm2/s、(2.142±0.150)×10-3mm2/s、(2.127±0.183)×10-3mm2/s、(2.079±0.119)×10-3mm2/s， 3.0T MR5个年龄段肾实质ADC值依次为(2.075±0.123)×10-3mm2/s、(2.066±0.117)×10-3mm2/s、(2.033±0.108)×10-3mm2/s、(1.971±0.127)×10-3mm2/s、(1.942±0.099)×10-3mm2/s。4、1.5T和3.0T健康肾脏ADC值测量Pearson相关系数为0.796。结论：3.0T肾脏DWI图像信噪比高于1.5T；同一b值（b=800s/mm2）条件下，1.5T和3.0T磁共振在不同部位和不同年龄段的肾脏ADC值差别不显著，，二者具有良好的一致性。
[Abstract]:Materials and Methods: From June 2012 to August 2013, a total of 100 healthy volunteers (50 males and 50 females, aged 18-69, average 44 years) were enrolled in this study. All the volunteers had normal renal function and no urinary system diseases or hypertension. The patients were divided into 5 groups (18-29 years old, 30-39 years old, 40-49 years old, 50-59 years old and 60-69 years old). The ADC values of renal parenchyma were measured and statistically analyzed by routine MR plain scan and RT-DWI on 3.0T MR scanner. 4) ((10-10-3 mm 2/s, (2.034 [(0.103) ((2.034 (0.103) [(2.034 (0.103) ((1.985 (0.172) ((1.985 (0.172) [(1.943 ((0.125) (0.125) (10-3 mm 2/s), (1.943 (0.125) ((F = 3.375, P 0.05). 2, the ADC values of renal parenchyrenal parenchymal ADC values of male kidnin five age groups were (2.087 ((2.087 ((0.-3mm2/s, (2.041 +0.205) *10-3mm2/s, (1.979) The ADC values of female renal parenchyma were (2.060.126) The ADC values of kidney parenchyma in healthy volunteers decreased with the increase of age, and there was no significant difference between the ADC values of men and women in the same age group.
Comparative study of 1.5T and 3.0T diffusion weighted imaging in kidney of second healthy volunteers
Materials and Methods: From June 2012 to December 2013, 150 healthy volunteers (75 males and 75 females, 18-73 years old, average 38 years old) were included in this study. They were divided into 5 groups according to their ages (18-29 years old, 30-39 years old, 40-49 years old, 50-59 years old and 60-69 years old). The same volunteer is in the same place.
FB-DWI and RT-DWI were performed on 1.5T and 3.0T magnetic resonance scanners (b values were 800s/mm2). Signal-to-noise ratios (SNR) of DWI images were compared by paired t test. The differences of ADC values in different parts of the kidney (upper, middle and lower) were compared by one-way ANOVA. Pearson correlation analysis was used to compare the ADC values measured at different field strengths. Results: 1, the SNR of FB-DWI images 3.0T and 1.5T MR were (66.500 + 14.776) and (51.570 + 8.578) respectively, the difference was statistically significant (P 0.05); the SNR of RT-DWI images 3.0T and 1.5T MR were (66.611 + 20.748) and (44.989 + 11.461), respectively, and the difference was statistically significant (P 0.05).
The ADC values of the upper, middle and lower parts of 2,1.5 T MR kidneys were (1.998 (+0.102), (1.998 (+0.102), (2.157 (+0.166), (2.157 (+0.166) (+10-3 mm2/s, (2.050 (+0.183) (+10-3 mm 2/s, (2.050 (+0.183) (+10-3 mm 2/s, (2.042 2.042 (+0.094) (+10-3 mm2/s,, (2.073 (+0.147) (+0.147)x 10-3 mm2/s, (1.947 /s, AD in three parts of the same field There was no significant difference in ADC values (1.5T:F=2.485, P 0.05; 3.0 T:F:F=3.107, P 0.05; 3.0 T:F=3.107, P 0.05). There was no significant difference in ADC values at the same part of kidnat different field intensities (P 0.05). The ADC values of renal parenchywas (2.165 +0.162) ((2.165 +0.162)x 10-3 mm2/s, (2.145 +0.157)x 10-3 mm2 / s, (2.142 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 150)x 10-10-3 mm2 / s, (2.150)x 10-3 mm2(2.079 + 0.119) * 10-3mm2/s,
The ADC values of kidney parenchyma in 5 age groups of 3.0T MR5 were (2.075 +0.123) ((2.075 +0.123)x 10-3 mm2/s, (2.066 +0.117)x 10-3 mm2/s, (2.033 [0.108)x 10-3 mm2/s, (2.033 [(2.033 [0.108)x 10-3 mm2/s, (1.971 [0.971 [0.127 [(1.971.971 [0.127) [(1.942 +0.099)x 10-3 mm2 / S 2 / s. 3 mm2 / s. 4 4, 1.942 The ratio is higher than 1.5T; the same b value (b=800s/mm2) 1.5T and 3.0T MR showed no significant difference in the ADC values of kidneys at different locations and at different ages, and the two had good consistency.
【学位授予单位】：中国人民解放军医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2
本文编号：2237220
[Abstract]:Materials and Methods: From June 2012 to August 2013, a total of 100 healthy volunteers (50 males and 50 females, aged 18-69, average 44 years) were enrolled in this study. All the volunteers had normal renal function and no urinary system diseases or hypertension. The patients were divided into 5 groups (18-29 years old, 30-39 years old, 40-49 years old, 50-59 years old and 60-69 years old). The ADC values of renal parenchyma were measured and statistically analyzed by routine MR plain scan and RT-DWI on 3.0T MR scanner. 4) ((10-10-3 mm 2/s, (2.034 [(0.103) ((2.034 (0.103) [(2.034 (0.103) ((1.985 (0.172) ((1.985 (0.172) [(1.943 ((0.125) (0.125) (10-3 mm 2/s), (1.943 (0.125) ((F = 3.375, P 0.05). 2, the ADC values of renal parenchyrenal parenchymal ADC values of male kidnin five age groups were (2.087 ((2.087 ((0.-3mm2/s, (2.041 +0.205) *10-3mm2/s, (1.979) The ADC values of female renal parenchyma were (2.060.126) The ADC values of kidney parenchyma in healthy volunteers decreased with the increase of age, and there was no significant difference between the ADC values of men and women in the same age group.
Comparative study of 1.5T and 3.0T diffusion weighted imaging in kidney of second healthy volunteers
Materials and Methods: From June 2012 to December 2013, 150 healthy volunteers (75 males and 75 females, 18-73 years old, average 38 years old) were included in this study. They were divided into 5 groups according to their ages (18-29 years old, 30-39 years old, 40-49 years old, 50-59 years old and 60-69 years old). The same volunteer is in the same place.
FB-DWI and RT-DWI were performed on 1.5T and 3.0T magnetic resonance scanners (b values were 800s/mm2). Signal-to-noise ratios (SNR) of DWI images were compared by paired t test. The differences of ADC values in different parts of the kidney (upper, middle and lower) were compared by one-way ANOVA. Pearson correlation analysis was used to compare the ADC values measured at different field strengths. Results: 1, the SNR of FB-DWI images 3.0T and 1.5T MR were (66.500 + 14.776) and (51.570 + 8.578) respectively, the difference was statistically significant (P 0.05); the SNR of RT-DWI images 3.0T and 1.5T MR were (66.611 + 20.748) and (44.989 + 11.461), respectively, and the difference was statistically significant (P 0.05).
The ADC values of the upper, middle and lower parts of 2,1.5 T MR kidneys were (1.998 (+0.102), (1.998 (+0.102), (2.157 (+0.166), (2.157 (+0.166) (+10-3 mm2/s, (2.050 (+0.183) (+10-3 mm 2/s, (2.050 (+0.183) (+10-3 mm 2/s, (2.042 2.042 (+0.094) (+10-3 mm2/s,, (2.073 (+0.147) (+0.147)x 10-3 mm2/s, (1.947 /s, AD in three parts of the same field There was no significant difference in ADC values (1.5T:F=2.485, P 0.05; 3.0 T:F:F=3.107, P 0.05; 3.0 T:F=3.107, P 0.05). There was no significant difference in ADC values at the same part of kidnat different field intensities (P 0.05). The ADC values of renal parenchywas (2.165 +0.162) ((2.165 +0.162)x 10-3 mm2/s, (2.145 +0.157)x 10-3 mm2 / s, (2.142 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 150)x 10-10-3 mm2 / s, (2.150)x 10-3 mm2(2.079 + 0.119) * 10-3mm2/s,
The ADC values of kidney parenchyma in 5 age groups of 3.0T MR5 were (2.075 +0.123) ((2.075 +0.123)x 10-3 mm2/s, (2.066 +0.117)x 10-3 mm2/s, (2.033 [0.108)x 10-3 mm2/s, (2.033 [(2.033 [0.108)x 10-3 mm2/s, (1.971 [0.971 [0.127 [(1.971.971 [0.127) [(1.942 +0.099)x 10-3 mm2 / S 2 / s. 3 mm2 / s. 4 4, 1.942 The ratio is higher than 1.5T; the same b value (b=800s/mm2) 1.5T and 3.0T MR showed no significant difference in the ADC values of kidneys at different locations and at different ages, and the two had good consistency.
【学位授予单位】：中国人民解放军医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2
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