不同时间段心肌梗死猪心肌收缩功能与心肌灌注关系的实验研究

发布时间：2018-10-05 12:27

【摘要】：目的应用心肌超声造影(MCE)评价心肌梗死猪不同时间段心肌收缩功能与心肌灌注的关系。方法将23只猪随机分为试验组及对照组,造模成功后的动物据不同的时间段随机分为6组,每组3只,行MCE,从MCE再灌注充盈曲线获得平台期强度(A值)、曲线上升率(β值)和心肌血流量(A值×β值)等参数进行分析。应用STI技术测定左室短轴乳头肌水平左室整体圆周应变(GCS)、整体径向应变(GRS)和左室心尖四腔心切面整体纵向应变(GLS)。结果与对照组相比,各实验组A、β、A×β、GCS、GRS、GLS、LVEF均下降;实验组LVEF、GCS、GRS和GLS与A×β有相关性(r=0.510、0.493、0.659和r=0.690,P0.05);各实验组LVEF、GCS、GRS和GLS与A值无相关性,与β值有相关性(r=0.550、0.595、0.534、0.629,P0.05)。结论心肌超声造影结合二维斑点追踪技术发现,不同时间段心肌梗死猪的心肌收缩功能变化与心肌灌注变化虽具有相关性,功能与灌注的变化却不是同步发生的,心肌收缩功能的改变早于且重于心肌灌注的改变。
[Abstract]:Objective to evaluate the relationship between myocardial contractile function and myocardial perfusion in myocardial infarction pigs by myocardial contrast echocardiography (MCE). Methods Twenty-three pigs were randomly divided into experimental group and control group. MCE, was performed to obtain the plateau strength (A value), curve rising rate (尾 value) and myocardial blood flow (A value 脳尾 value) from the filling curve of MCE reperfusion. Application of STI technique to the measurement of global (GCS), radial strain (GRS) and global longitudinal strain (GLS). Of left ventricular short axis papillary muscle horizontal left ventricular circular strain (GCS), and left ventricular apical four chamber sectional plane Results compared with the control group, the levels of LVEF,GCS,GRS and GLS in the experimental group were significantly lower than those in the control group (r 0.510 0. 493 0. 659 and 0. 690 0. 05), but there was no correlation between LVEF,GCS,GRS and GLS in each experimental group, but there was a correlation between LVEF,GCS,GRS and 尾 value (r 0. 550, 0. 595, 0. 534, 0. 629 (P0.05). Conclusion Myocardial contrast echocardiography combined with two dimensional speckle tracing technique shows that the changes of myocardial contractile function and myocardial perfusion in different periods of myocardial infarction pigs are correlated, but the changes of myocardial function and perfusion do not occur at the same time. The changes of myocardial contractile function were earlier and more serious than the changes of myocardial perfusion.
【作者单位】：新疆医科大学第一附属医院超声医学中心心脏超声诊断科;
【基金】：国家自然科学基金资助(No.81271590)
【分类号】：R542.2;R445.1

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