白塞病心脏瓣膜损害及其超声心动图评价

发布时间：2018-10-08 07:36

【摘要】：目的：分析白塞病以心脏瓣膜损害为主要表现的临床特点及超声心动图改变。方法：回顾分析2006-2012年我院以心脏瓣膜损害为突出表现收治且诊断白塞病的21例患者的临床资料。结果：本组患者中男性17例,女性4例,平均年龄39.5岁。21例患者均表现出主动脉瓣反流,反流量中量至大量,超声心动图无特征性改变,多表现为主动脉瓣脱垂。5例非手术治疗,16例手术治疗。主动脉瓣位人工瓣置换22例次,术后均发生瓣周漏；1例主动脉根部置换术,结合围手术期免疫抑制治疗效果良好；3例行心脏移植,术后早期心功能良好,无排异。住院期间2例分别因换瓣术后低心排、动脉瘤破裂死亡。随访期间有10例换瓣术后患者主动脉瓣位人工瓣瓣周仍有明显反流。结论：白塞病心血管系统受累的表现缺乏特异性。以心脏瓣膜损害为突出表现的非风湿性非先天性主动脉瓣反流者,尤其是年轻患者,应警惕为白塞病所致。
[Abstract]:Objective: to analyze the clinical features and echocardiographic changes of Behcet's disease. Methods: the clinical data of 21 patients with Behcet's disease admitted to our hospital from 2006 to 2012 were retrospectively analyzed. Results: there were 17 males and 4 females with an average age of 39.5 years. 21 patients showed aortic valve regurgitation with moderate to large volume of regurgitation and no characteristic changes in echocardiography. Most of them showed aortic valve prolapse. 5 cases were treated by non-operation and 16 cases were treated surgically. Aortic valve replacement was performed in 22 cases. Perivalvular leakage occurred in 1 case. Combined with perioperative immunosuppressive therapy, cardiac transplantation was performed in 3 cases. Cardiac function was good in the early postoperative period without rejection. Two patients died of rupture of aneurysm after valve replacement. During the follow-up period, 10 patients with aortic valve prosthesis still had significant regurgitation after valve replacement. Conclusion: the manifestation of cardiovascular system involvement in Behcet's disease is not specific. Non-rheumatic non-congenital aortic valve regurgitation, especially in young patients, should be on guard against Behcet's disease.
【学位授予单位】：北京协和医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R597.9;R540.45

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