屏气fMRI评价2型糖尿病患者脑血管反应能力
发布时间：2018-10-15 19:39
【摘要】：目的利用fMRI结合屏气方法评价2型糖尿病(T2DM)患者的脑血管反应能力(CVR)。方法对25例T2DM患者(T2DM组)和25名健康志愿者(对照组)进行屏气条件下的fMRI试验。采用SPM8进行数据处理和统计分析,组内分析采用单样本t检验,组间分析采用双样本t检验。将存在CVR组间差异的脑区建立为ROI,提取所有受试者的BOLD信号变化百分比(PSC),比较组间ROI内平均PSC的差异,并将T2DM组的PSC与临床行为学、心理学及血糖控制水平进行相关分析。结果无并发症的T2DM患者与对照组的CVR分布均以灰质为主(P0.05,FWE校正),T2DM组双侧前额叶内侧面及背外侧面的CVR明显高于对照组(P0.01,AlphaSim校正),该区域的PSC与临床行为学、心理学和血糖控制水平之间无相关性。结论屏气fMRI可用于评价CVR,无明显并发症的T2DM患者双侧前额叶的CVR升高,可能处于代偿期,有发生记忆和执行功能障碍的风险。
[Abstract]:Objective to evaluate the cerebrovascular response ability (CVR).) of type 2 diabetes mellitus (T2DM) patients by fMRI combined with breath-holding method. Methods fMRI test was performed on 25 T2DM patients (T2DM group) and 25 healthy volunteers (control group). SPM8 was used for data processing and statistical analysis. Single sample t-test was used for intra-group analysis and two-sample t-test was used for inter-group analysis. The brain region with difference in CVR was established as the percentage of BOLD signal change in all subjects extracted by ROI,. The average PSC in ROI was compared between the two groups by (PSC), and the correlation between PSC and clinical behavior, psychology and blood glucose control level in T2DM group was analyzed. Results the distribution of CVR in T2DM patients without complications was mainly gray matter (P0.05 FWE correction). The CVR in bilateral medial prefrontal lobe and dorsolateral side of T2DM group was significantly higher than that in control group (P0.01 AlphaSim correction). PSC and clinical behavior in this area were significantly higher than those in control group. There was no correlation between psychology and blood glucose control levels. Conclusion breath-holding fMRI can be used to evaluate the increase of CVR in bilateral prefrontal lobe of T2DM patients without obvious complications, which may be in compensatory stage and may have the risk of memory and executive dysfunction.
【作者单位】： 天津医科大学总医院放射科天津市功能影像重点实验室;天津医科大学代谢病医院放射科;天津医科大学代谢病医院心脏科;
【分类号】：R587.2;R445.2
[Abstract]:Objective to evaluate the cerebrovascular response ability (CVR).) of type 2 diabetes mellitus (T2DM) patients by fMRI combined with breath-holding method. Methods fMRI test was performed on 25 T2DM patients (T2DM group) and 25 healthy volunteers (control group). SPM8 was used for data processing and statistical analysis. Single sample t-test was used for intra-group analysis and two-sample t-test was used for inter-group analysis. The brain region with difference in CVR was established as the percentage of BOLD signal change in all subjects extracted by ROI,. The average PSC in ROI was compared between the two groups by (PSC), and the correlation between PSC and clinical behavior, psychology and blood glucose control level in T2DM group was analyzed. Results the distribution of CVR in T2DM patients without complications was mainly gray matter (P0.05 FWE correction). The CVR in bilateral medial prefrontal lobe and dorsolateral side of T2DM group was significantly higher than that in control group (P0.01 AlphaSim correction). PSC and clinical behavior in this area were significantly higher than those in control group. There was no correlation between psychology and blood glucose control levels. Conclusion breath-holding fMRI can be used to evaluate the increase of CVR in bilateral prefrontal lobe of T2DM patients without obvious complications, which may be in compensatory stage and may have the risk of memory and executive dysfunction.
【作者单位】： 天津医科大学总医院放射科天津市功能影像重点实验室;天津医科大学代谢病医院放射科;天津医科大学代谢病医院心脏科;
【分类号】：R587.2;R445.2
【共引文献】
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1 尚延昌;王淑辉;高中宝;周波;郭艳娥;王炜;解恒革;王振福;吴卫平;;糖尿病与高龄老年人群认知功能障碍发生的相关性[J];分子影像学杂志;2014年04期
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