动态增强MRI定量参数对不同组织学类型肺癌的诊断价值

发布时间：2018-10-26 11:20

【摘要】：目的研究3.0T磁共振定量分析在肺癌诊断中的价值和作用,为临床肺癌的早期诊断提供新的依据。方法选取经病理证实的肺癌患者20例,行MR平扫及动态增强扫描,通过后处理软件获得每个病灶及胸壁肌肉组织的定量参数(Ktrans、Kep、Ve、i AUC),所有肺癌患者均经手术或者穿刺取得病理结果,比较不同类型肺癌及胸壁组织间的定量参数值,各组数据之间通过单因素方差分析比较,确定肺鳞癌与腺癌诊断的最佳定量参数值。结果鳞癌、腺癌与胸壁之间定量参数值差异有统计学意义(P0.05),鳞癌、腺癌Ktrans、Kep、Ve、i AUC值均高于胸壁肌肉组织;鳞癌、腺癌之间Ktrans、Kep、i AUC差异有统计学意义(P0.05),其中Ktrans值敏感度、特异度最高,分别为76.9%、100.0%;Ve差异无统计学意义(P0.05);鳞癌、腺癌的鉴别诊断中各定量参数的界值分别为:Ktrans(0.134)、Kep(0.361)、i AUC(22.409)。结论定量参数值对肺癌的早期诊断及鳞癌、腺癌的鉴别诊断具有重要临床意义。
[Abstract]:Objective to study the value and role of 3.0T magnetic resonance quantitative analysis in the diagnosis of lung cancer, and to provide a new basis for early diagnosis of clinical lung cancer. Methods Twenty patients with lung cancer confirmed by pathology were examined by MR plain scan and dynamic enhanced scanning. The quantitative parameters (Ktrans,Kep,Ve,i AUC),) of each lesion and chest wall muscle tissue were obtained by post-processing software. All patients with lung cancer underwent surgery or puncture to obtain pathological results. The quantitative parameters of different types of lung cancer and chest wall tissues were compared. The data of each group were compared by single factor ANOVA. To determine the best quantitative parameters for the diagnosis of lung squamous cell carcinoma and adenocarcinoma. Results there was significant difference in quantitative parameters between squamous cell carcinoma, adenocarcinoma and chest wall (P0.05). The Ktrans,Kep,Ve,i AUC value of squamous cell carcinoma and adenocarcinoma was higher than that of chest wall muscle tissue. The difference of Ktrans,Kep,i AUC between squamous cell carcinoma and adenocarcinoma was statistically significant (P0.05), among which the sensitivity and specificity of Ktrans value was the highest, which was 76.9% and 100.0V, respectively. There was no significant difference between them (P0.05). The cutoff values of quantitative parameters in differential diagnosis of squamous cell carcinoma and adenocarcinoma were: Ktrans (0.134), Kep (0.361), i AUC (22.409 respectively. Conclusion quantitative parameters are important for early diagnosis of lung cancer and differential diagnosis of squamous cell carcinoma and adenocarcinoma.
【作者单位】：桂林医学院附属医院放射科;
【基金】：广西壮族自治区卫生厅自筹经费科研课题(编号:Z2013515)
【分类号】：R445.2;R734.2

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