40岁以下青年乳腺癌超声表现与分子亚型的关系

发布时间：2018-10-31 15:05

【摘要】：目的探讨40岁以下青年乳腺癌的超声图像特征与分子亚型间的关系。方法回顾性分析136例(144个病灶)40岁以下青年乳腺癌的超声图像特征,并分析其与分子亚型的关系。结果 1本组青年乳腺癌多表现为中高级别(107/109,98.17%)的浸润性导管癌(111/144,77.08%);2Luminal A型占58.12%(68/117),Luminal B型11.97%(14/117),HER2过表达型13.68%(16/117),三阴型16.24%(19/117);3以低回声(121/132,91.67%)、肿块形式(132/144,91.67%)出现是本组青年乳腺癌最常见的超声征象;三阴型乳腺癌出现微钙化的概率小(7/19,36.84%,P=0.006),多表现为形态规则(14/19,73.68%,P=0.001)、体积较大[最大径线5cm为26.32%(5/19),P=0.038]、边界清晰(13/19,68.42%,P=0.158)、后方无声衰减(19/19,100%,P=0.358)的肿块;HER2过表达型表现为非肿块的比例高(4/16,25.00%,P=0.040),且75.00%(9/12)的HER2过表达型肿块出现微钙化(P=0.824);与其他两型比较,Luminal型多表现为乏血供、小体积形式(P均0.05),且出现微钙化比例相对较大(Luminal A:70.31%,Luminal B:63.64%),但与非Luminal型比较差异无统计学意义(P=0.056)。结论青年乳腺癌具较高侵袭性,其超声图像特征与分子亚型有一定关系。
[Abstract]:Objective to investigate the relationship between ultrasonic imaging features and molecular subtypes of breast cancer under 40 years old. Methods the ultrasonographic features of 136 cases (144 lesions) of breast cancer under 40 years old were analyzed retrospectively and their relationship with molecular subtypes was analyzed. Results (1) the most common manifestations of breast cancer in this group were middle and high grade (107 / 109) and invasive ductal carcinoma (111 / 144) (77.08%). 2Luminal A accounted for 58.12% (68 / 117), Luminal B 11.97%, 14 / 117), HER2 overexpression 13.68% (16 / 117), triple negative 16.24% (19 / 117). 3 hypoechoic (121 / 132) and mass (132 / 144 / 91.67%) were the most common ultrasound signs of young breast cancer. The probability of microcalcification in triple negative breast cancer is small (7 / 19 / 36.84 / P0. 006), and most of them are regular in shape (14 / 19, 73.68%, P0. 001), larger in volume [maximum diameter 5cm is 26.32% (5 / 19), P0. 038]. A mass with a clear boundary (13 / 19 / 68.42) and a silent attenuation in the rear (19 / 100); The rate of HER2 overexpression was high (4 / 16 / 25.00) and microcalcification was found in 75.00% (9 / 12) of HER2 overexpressed tumors (P0. 824). Compared with the other two types, the Luminal type showed lack of blood supply, small volume (all P 0.05), and a relatively large proportion of microcalcification (Luminal A: 70.31) (63.64% of Luminal B: 1). But there was no significant difference compared with non-Luminal type (P0. 056). Conclusion Young breast cancer is highly invasive, and its ultrasonographic features are related to molecular subtypes.
【作者单位】：南方医科大学南方医院超声科;广州市第一人民医院超声医学科;
【分类号】：R737.9;R445.1

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