动脉自旋标记脑灌注技术在快速动眼睡眠障碍研究中的应用

发布时间：2018-11-02 20:08

【摘要】：目的:采用磁共振动脉自旋标记技术(ASL)对快速动眼睡眠障碍(R BD)患者的脑血流灌注异常情况进行研究,探讨ASL的应用价值。方法:我们的研究包括经同步视频多导睡眠监测(PSG)证实的原发性RBD患者20例及年龄、性别与RBD患者匹配的健康志愿者15例。所有的被试均在GE Discovery MR750磁共振扫描仪上进行ASL序列和3D-BRAVO序列的扫描。ASL的数据分析采用基于体素的方法在SPM8软件上进行。RBD组和对照组被试脑皮质灌注的差异采用双样本t检验进行分析。结果:RBD患者皮质灌注增高的区域主要位于额叶、前扣带皮质、辅助运动区、壳核、海马旁回、楔前叶和脑桥等;皮质灌注降低的区域主要位于枕叶、舌叶、颞叶中部等。结论:ASL技术可以发现RBD患者的灌注异常,在神经退行性病变的研究方便有较大的应用价值。
[Abstract]:Objective: to study the abnormal cerebral blood flow perfusion in patients with REM sleep disorder (R BD) by magnetic resonance arterial spin labeling (ASL), and to explore the value of ASL. Methods: our study included 20 patients with primary RBD confirmed by synchronous video polysomnography (PSG) and 15 healthy volunteers with age and sex matched with RBD patients. All subjects were scanned with ASL and 3D-BRAVO sequences on GE Discovery MR750 MRI scanner. ASL data analysis was performed on SPM8 software using a voxel based method. The difference in cerebral cortex perfusion between RBD group and control group was observed. Double sample t test was used for analysis. Results: the areas of increased cortical perfusion in RBD patients were mainly located in frontal lobe, anterior cingulate cortex, auxiliary motor area, putamen nucleus, perihippocampal gyrus, precuneiform lobe and pons, and the regions of decreased cortical perfusion were mainly located in occipital lobe, lingual lobe, middle temporal lobe, etc. Conclusion: ASL technique can find abnormal perfusion in patients with RBD, and it is of great value in the study of neurodegenerative diseases.
【作者单位】：复旦大学附属华山医院放射科;复旦大学附属华山医院PET中心;复旦大学附属华山医院神经内科;上海联影医疗科技有限公司;
【基金】：上海市科委重点科技攻关项目,编号11441901402 国家自然科学基金,编号81361120393~~
【分类号】：R445.2;R740

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