三维伪连续性动脉自旋标记磁共振灌注成像联合扩散加权成像在脑胶质瘤分级中的价值

发布时间：2018-11-04 15:13

【摘要】：目的 :评价联合三维伪连续性动脉自旋标记磁共振灌注成像(3D p CASL)和扩散加权成像(DWI)技术在脑胶质瘤分级中的价值。方法 :对经手术切除病理证实的37例脑胶质瘤病人(19例高级别胶质瘤和18例低级别胶质瘤)在术前行磁共振3D p CASL、DWI和常规序列的扫描。将感兴趣区置于脑胶质瘤的实性部分并分别进行定量测量得到血流量(CBF)和表观扩散系数(ADC)值。分别比较CFB和ADC值在高、低级别脑胶质瘤中的差异。利用Binary逻辑回归和受试者特征曲线(ROC)分析CBF、ADC值和CBF联合ADC值在高、低级别脑胶质瘤分级中的价值。结果 :CBF值在高级别脑胶质瘤中(85.3±19.2 ml/min/100g)显著高于在低级别脑胶质瘤中(43.5±11.2 ml/min/100g)(P0.01)。ADC值在高级别胶质瘤中(0.0009±0.0002mm2/s)显著低于在低级别脑胶质瘤中(0.0014±0.0004 mm2/s)(P0.01)。ROC曲线分析显示,在对高、低级别脑胶质瘤的分级中,CBF联合ADC值的曲线下面积显著大于CBF或ADC值的(P0.05),CBF联合ADC值的敏感性和特异性均大于单独使用CBF或ADC值。结论 :三维伪连续性动脉自旋标记灌注磁共振成像和扩散加权成像均有助于脑胶质瘤的分级。与单独使用CBF或ADC值相比,CBF联合ADC值可以显著提高对脑胶质瘤进行分级的能力。
[Abstract]:Aim: to evaluate the value of three-dimensional pseudo-continuous arterial spin-labeled magnetic resonance perfusion imaging (3D p CASL) and diffusion-weighted imaging (DWI) in the grading of gliomas. Methods: 37 patients with glioma (19 high-grade gliomas and 18 low-grade gliomas) confirmed by surgery and pathology were examined with 3D p CASL,DWI and conventional sequence before operation. The region of interest was placed in the solid part of glioma and the (CBF) and (ADC) values of blood flow were measured quantitatively. The differences of CFB and ADC in high and low grade gliomas were compared. Binary logical regression and (ROC) were used to analyze the value of CBF,ADC and CBF combined with ADC in high and low grade glioma grading. Results: the CBF value in high-grade gliomas (85.3 卤19.2 ml/min/100g) was significantly higher than that in low-grade gliomas (43.5 卤11.2 ml/min/100g). 0009 卤0.0002mm2/s was significantly lower than that in low-grade gliomas (0.0014 卤0.0004 mm2/s) (P0.01). ROC curve analysis showed that, In the classification of high and low grade gliomas, the area under the curve of CBF combined with ADC was significantly larger than that of CBF or ADC (P0.05) the sensitivity and specificity of), CBF combined with ADC were higher than those of CBF or ADC alone. Conclusion: 3D pseudo-continuous arterial spin-labeled perfusion magnetic resonance imaging and diffusion-weighted imaging are helpful to grade gliomas. Compared with CBF or ADC alone, CBF combined with ADC significantly improved the ability to grade gliomas.
【作者单位】：西安交通大学生命科学与技术学院;河南省人民医院放射科;西安交通大学生命科学与技术学院生物医学信息工程教育部重点实验室;
【基金】：国家自然科学基金(No.81271565)~~
【分类号】：R445.2;R739.41

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