不同睡眠状态对卵泡期女性悲伤面孔识别影响的功能核磁共振成像研究

发布时间：2018-11-05 09:00

【摘要】：目的：探讨不同睡眠状态下，青年女性卵泡期悲伤面孔识别差异脑区，为女性睡眠与情绪疾病之间的相关机制提供理论依据。对象：招募大连医科大68名健康女生志愿者为研究对象，根据匹兹堡睡眠量表、明尼苏达多项人格问卷、特质焦虑状态问卷、生活事件、月经周期曲线评估，筛查出16名健康女生进入实验组，在下一次月经的卵泡期，所有被试进入脑功能实验。方法：实验设计为自身对照研究，在三种状态下观察不同睡眠状态下情感面孔识别差异。即：正常睡眠、24小时睡眠剥夺和4小时睡眠恢复三种状态下观看中性—悲伤情绪面孔图片，同时行3.0T脑功能磁共振扫描收集激活的影像数据。使用SPM8软件处理数据，进行分析。结果：1.各量表分值比较：①主观睡眠评分：单因素方差分析显示差异显著（P0.05）；②状态焦虑评分：正常睡眠组和睡眠剥夺组、正常睡眠组和睡眠恢复组间差异显著（P0.05），而睡眠剥夺组和睡眠恢复组差异不显著（P0.05）；③心境状态评分（7个分量）：睡眠剥夺组和睡眠恢复组的紧张、愤怒、疲劳差异显著（P0.05），但是，正常睡眠组和睡眠恢复组上述差异不显著（P0.05）。正常睡眠组和睡眠剥夺组疲劳、慌乱和精力差异显著（P0.05）；2.悲伤情绪刺激任务下激活增强的脑区：（1）睡眠剥夺组-正常睡眠组：左侧扣带回中部及其侧面环绕的脑回、小脑脚1区和前叶4、5区、旁中央小叶、辅助运动区和中央后回；右侧杏仁核、扣带回前部及其侧面环绕的脑回，小脑蚓部6区，海马，额中回、中央前回和内侧额上回（中性）；右侧内侧额上回、扣带回（前、中部）及其侧面环绕的脑回，左侧下叶核外白质、杏仁核（悲伤）；正常睡眠组-睡眠剥夺组：右侧颞叶角回（悲伤）；左右两侧矩状裂及其周围皮层；。（2）睡眠恢复组-正常睡眠组：左侧下叶屏状核灰质、小脑蚓部3区和海马；右侧下叶核外白质、额叶深部白质和小脑前叶4、5区（悲伤）。左侧颞上回白质、小脑脚1区和小脑后叶8区；右侧矩状裂及其周围皮层，中央前回、额叶深部白质、辅助运动区，枕上回，下叶海马，梭状回（中性）；正常睡眠组-睡眠恢复组：无（悲伤和中性）。（3）睡眠恢复组-睡眠剥夺组：左侧额叶罗兰多壳盖，右侧颞下回、颞中回（中性）；左侧额叶罗兰多壳盖区，右侧下叶核外白质（悲伤）。睡眠剥夺组-睡眠恢复组：左侧前扣带回白质、下叶核外白质和扣带回中部及其侧面环绕的脑回，右侧扣带回前部及其侧面环绕的脑回（中性）和无（悲伤）。结论： 1.24小时睡眠剥夺能够主观体验到焦虑，紧张、愤怒、疲劳、慌乱和精力下降，而4小时的睡眠恢复能缓解其中的紧张、愤怒、疲劳几乎达到睡眠正常的水平； 2.女性左右两侧大脑均参与了对悲伤情绪的加工，且不同的睡眠状态下对悲伤情绪加工脑区存在部位、数量及强度的差异。女性大脑机能低于正常状态时，识别面孔情绪的能力减低，识别加工需要更多脑区域参与，以及更强烈的激活（中性更甚于悲伤，出现悲伤化漂移），这些脑区包括边缘系统、额叶、颞叶、小脑。女性大脑机能处于高于常人水平状态时，完成同样的任务只需要较少的脑区参与，表现为节约及高效； 3.女性悲伤情绪加工，短暂的睡眠恢复可以选择地降低睡眠剥夺下脑区出现的激活强度，，但其部位并非完全重叠，倾向于基本恢复正常的情绪加工的能力； 4.女性在睡眠剥夺与睡眠恢复脑区激活程度与主观体验之间存在一定差异。
[Abstract]:Objective: To explore the different brain regions in the follicular phase of young women in different sleep states, and to provide a theoretical basis for the correlation mechanism between sleep and mood disorders in women. PARTICIPANTS: A total of 68 healthy female volunteers from Dalian Medical College were recruited as research subjects. According to Pittsburgh Sleep Scale, Minnesota Multipersonality Questionnaire, Special Anxiety Status Questionnaire, Life Events, menstrual cycle curve assessment, 16 healthy female students were screened for entry. The test group, during the follicular phase of the next menstrual cycle, all tested into the brain function Experiment. Methods: The experimental design is a self-control study, and the emotion surface in different sleep states is observed in three states. Hole recognition differences: Normal sleep, 24-hour sleep deprivation, and 4-hour sleep recovery three state-of-the-art sad emotional face images while line 3. 0T brain function magnetic resonance scan collection activation Image data. Use SPM8 software to process data and analyze Results: 1. The scores of each scale were compared with the scores of individual scales: single-factor analysis of variance showed significant difference (P 0.05), and anxiety scale: normal sleep group and sleep deprivation group, normal sleep group and sleep recovery group. There was no significant difference between sleep deprivation group and sleep recovery group (P 0.05), but there was no significant difference between sleep deprivation group and sleep recovery group (P <0.05). However, the difference between sleep deprivation group and sleep recovery group was significant (P <0.05). However, the difference between sleep deprivation group and sleep recovery group was not significant. (P 0.05). The differences of fatigue, panic and energy in normal sleep group and sleep deprivation group were significant (P <0.05). P0. 05); 2. Activation of the enhanced brain region under the grief-emotional stimulation task: (1) Sleep deprivation group-Normal sleep group: left-handed buckle back center and side-surrounding brain-back, cerebellar peduncle 1 region and anterior lobe 4, 5 region, bypass central lobules, auxiliary motion region, and center posterior return; right lateral incisor, buckle back to the anterior and lateral surface of the brain, cerebellar vermis 6 region, hippocampus, forehead, central anterior and medial frontal (neutral); right medial frontal, buckle back (front, middle), and side-surrounding brain back, left lower leaf nucleus outer white matter (sadness); normal sleep group-sleep deprivation group: right hand corner back (sadness); left and right moment shape fissure and peripheral cortex; (2) sleep recovery group-normal sleep group: left lower leaf screen-like nucleus gray matter, cerebellar vermis 3 region and hippocampus; right inferior leaf nucleus outer white matter, frontal lobe white matter and cerebellar anterior leaflet 4, 5 regions (Sadness). Left white matter, white matter, cerebellum foot 1 region and cerebellum posterior lobe 8 region; right moment fissure and peripheral cortex, anterior frontal white matter, auxiliary exercise region, pillow top back, lower lobe hippocampus, shuttle back (neutral); normal sleep group-sleep recovery group: No (sad and neutral). (3) Sleep recovery group-Sleep deprivation group: Loren multi-shell cover on left frontal lobe, right side of Loren multi-shell cover area, right inferior lobe White white matter (sadness). Sleep deprivation group-Sleep recovery group: left anterior cingback white matter, lower leaf nucleus outer white matter and buckle back center and its side-surrounding brain back, right buckle back to the front and its side surround brain back (middle Sex) and No (sad). Conclusion: 1. 24-hour sleep deprivation can experience anxiety, stress, anger, fatigue, panic and energy decline, while sleep recovery at 4 hours can ease tension, anger, and the left and right sides of the woman participate in the processing of the sad emotion, There is a difference in location, quantity, and intensity in the processed brain region. When the female brain function is lower than the normal state, the ability to recognize facial emotion is reduced, recognition processing requires more brain regions participation, and more intense activation (neutral more than sadness, occurrence of sadness drift), these The brain area includes limbic system, frontal lobe, amygdala, cerebellum. When female brain function is higher than normal person's level, it only needs to complete the same task less brain regions are involved in savings and high efficiency; 3. Women's sad emotional processing, transient sleep recovery may to selectively reduce the intensity of activation of the brain region under sleep deprivation, but the portion thereof is not completely the ability to work with basic normal emotions; 4. Women are deprived of sleep by sleep.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R740;R445.2

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