Gd-EOB-DTPA （钆塞酸二钠注射液）对肝脏病变的检出价值：磁共振平扫与Gd-EOB-DTPA增强扫描的对比研究

发布时间：2018-11-06 17:09

【摘要】：题目：普美显(钆塞酸二钠注射液)对肝脏病变的检出价值：磁共振平扫与普美显增强扫描的对比研究目的：本研究的目的是比较使用普美显增强后的肝细胞期与磁共振平扫及普美显增强扫描其它动态时相所发现肝脏病灶的敏感性。设计：回顾性研究材料和方法：收集所有行MRI平扫及普美显对比增强的肝病患者的磁共振图像资料。采用双盲法,3位阅片者在不同的环境下分别阅读不同序列的图像,并记录下病变的数目、部位及大小等特征。为了避免记忆产生的偏差,将平扫、增强扫描动脉期以及肝细胞期分别间隔一周后再给阅片者阅读。当每个患者完成检查后,3位阅片者一起再次仔细的阅片然后确定病灶数目,建立一个参考标准。病人的临床资料和报告也要考虑,还要参考以前的学者的研究。病灶数目,部位及磁共振的其它一些发现被认为是建立参考标准最有价值的参数。阅片者依照参考标准将每位患者的磁共振图像进行阅片分析得出不同磁共振扫描序列及方法所发现病灶的敏感性。最后,运用统计分析软件SPSS16.0进行统计分析,比较磁共振平扫和使用普美显对比增强后不同时相所发现病灶的敏感性差异,统计学方法使用Wilcoxon秩和检验,设定P0.05差异有统计学意义。结果：使用普美显对比增强后的肝细胞期比磁共振平扫及普美显增强扫描其它动态时相发现了更多的病灶。普美显增强后的肝细胞期所发现的病灶的敏感性与参考标准相比较,差异没有统计学意义；但是磁共振平扫及普美显增强扫描后的其它动态时相与参考标准相比较,差异有统计学意义。结论：在发现肝脏病灶方面,普美显磁共振增强扫描肝细胞期比磁共振平扫及普美显磁共振增强扫描其它动态时相具有更高敏感性。
[Abstract]:Topic: the value of promestrine (gadolinium disodium injection) in the detection of hepatic lesions: a comparative study of plain MRI and prednisone contrast study objective: this study was to compare the liver with prednisone. Sensitivity of cell phase and Mr plain scan and PFM enhancement to other dynamic phases in detecting liver lesions. Design: retrospective study materials and methods: MRI images were collected from all patients with liver disease who underwent MRI plain scan and plain contrast enhancement. Using the double blind method, the three film-readers read the images of different sequences in different environments, and recorded the number, location and size of the lesions. In order to avoid the deviation of memory, scan, enhance the arterial phase and hepatocyte phase one week interval and then give the reader reading. After each patient has completed the examination, the three radiographers carefully read the film again and then determine the number of lesions and establish a reference standard. Patient clinical data and reports should also be considered, as well as previous studies by scholars. The number, location and other findings of MRI are considered to be the most valuable parameters for establishing reference criteria. According to the reference criteria, the radiographs of each patient were analyzed to determine the sensitivity of different MRI sequences and methods. Finally, statistical analysis software SPSS16.0 was used to compare the sensitivity differences between plain MRI and plain contrast enhancement. Wilcoxon rank sum test was used for statistical analysis. Set P0.05 difference was statistically significant. Results: more lesions were found in the hepatocyte phase after contrast enhancement than that in the normal MRI and other dynamic phase. There was no significant difference between the sensitivity of the liver cell phase and the reference criteria. However, there were significant differences between the other dynamic phase and the reference standard. Conclusion: in the detection of hepatic lesions, the phase of hepatocytes on Mr enhanced Mr is more sensitive than that on plain MRI and other dynamic phases.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2

【参考文献】