小视野体素内不相干运动MRI在宫颈癌术前分级中的可行性

发布时间：2018-11-10 19:44

【摘要】：目的探讨小视野体素内不相干运动(IVIM)MRI在宫颈癌术前分级的可行性。资料与方法收集经手术病理证实的23例宫颈癌患者,术前行MRI常规序列及IVIM序列扫描,IVIM序列包括10个b值(0~1500 s/mm2),根据肿瘤分化程度将患者分为高分化组(I级)10例和中低分化组(II、III级)13例。计算高分化组、中低分化组的表观扩散系数(ADC)standard值、慢速表观扩散系数D值、快速表观扩散系数D*值和灌注分数f值,采用受试者工作特征(ROC)曲线下面积评价参数价值的准确性。结果中低分化组的ADCstandard值、D值与高分化组比较,差异有统计学意义(t=140.5、129.5,P0.05);ADCstandard值、D值的曲线下面积分别为0.965和0.854,高分化组和中低分化组的敏感度和特异度分别为88.9%、100.0%和77.8%、81.8%;D*值和f值组间差异无统计学意义(t=-0.184、1.072,P0.05)。结论小视野IVIM MRI技术在术前预测宫颈癌的高、中低分化程度是可行的。
[Abstract]:Objective to investigate the feasibility of small-field voxel (IVIM) MRI in preoperative classification of cervical cancer. Materials and methods 23 patients with cervical cancer confirmed by surgery and pathology were examined by MRI routine sequence and IVIM sequence before operation. IVIM sequence included 10 b values (0 ~ 1500 s/mm2). According to the degree of tumor differentiation, the patients were divided into high differentiation group (grade I) and low differentiation group (II,III grade). The apparent diffusion coefficient (ADC) standard), the slow apparent diffusion coefficient (D), the fast apparent diffusion coefficient (D *) and the perfusion fraction (f) were calculated. The accuracy of the value of the parameters was evaluated by using the area under the (ROC) curve of the operating characteristics of the subjects. Results the ADCstandard value and D value of middle and low differentiation group were significantly different from those of high differentiation group (T140.5129.5). The area under the curve of ADCstandard value and D value were 0.965 and 0.854 respectively. The sensitivity and specificity of high differentiation group and low differentiation group were 88. 9% and 78. 8% respectively. There was no significant difference in D * value and f value between the two groups (t = -0.184 or 1.072 P 0.05). Conclusion it is feasible to predict the degree of differentiation of cervical cancer by small field IVIM MRI before operation.
【作者单位】：河北省邯郸市中心医院CT室;
【基金】：邯郸市科技计划项目(1423108062-6)
【分类号】：R445.2;R737.33

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