成年正常胰腺多b值DWI参数与性别、年龄的相关性研究

发布时间：2018-11-15 20:34

【摘要】：目的:探讨性别、年龄因素对成年正常胰腺多b值DWI参数的影响。方法:回顾性分析57例胰腺正常患者(男36例,年龄21~68岁,平均43.9±11.4岁;女21例,年龄24~59岁,平均46.8±9.7岁)的临床及影像资料,利用上腹部多b值DWI(b值=0、20、50、100、200、400、600、800及1000s/mm2)测量每个患者从胰腺头到尾部单指数模型参数ADCtotal值和双指数模型参数ADCfast、ADCslow和f值,并计算每个胰腺平均ADCtotal、ADCfast、ADCslow和f值。使用独立样本t检验分析不同性别患者的年龄分布差异;采用独立样本非参数Mann-Whitney U检验分析不同性别间各参数平均值差异;利用Pearson相关分析方法分析平均ADCtotal、ADCfast、ADCslow和f值与年龄的相关性。结果:女性正常胰腺平均ADCtotal、ADCfast、ADCslow和f值[分别为(1.45±0.15)×10-3、(13.17±4.91)×10-3、(0.88±0.18)×10-3 mm2/s和(0.370±0.063)]皆低于男性[分别为(1.55±0.17)×10-3、(15.77±7.83)×10-3、(0.91±0.15)×10-3 mm2/s和(0.372±0.056)],但男、女性间各参数平均值均无显著性差异(P均0.05)。Pearson相关分析表明成年正常胰腺平均ADCtotal、ADCfast和ADCslow值与年龄有显著相关性(相关系数r分别为:-0.315、-0.340和-0.300;P值分别为0.017、0.010和0.023);f值与年龄无显著相关性(相关系数r=0.048,P=0.725)。结论:成年正常胰腺平均ADCtotal、ADCfast和ADCslow随着年龄增加而减小。利用多b值DWI研究胰腺相关疾病时,不可忽略志愿者年龄因素对ADCtotal、ADCfast和ADCslow的影响。
[Abstract]:Objective: to investigate the effect of sex and age on multib DWI parameters of adult normal pancreas. Methods: 57 cases of normal pancreas (36 males, aged 21 68 years, mean 43.9 卤11.4 years) were analyzed retrospectively. The clinical and imaging data of 21 females, aged 24 to 59 years (mean 46.8 卤9.7 years), were measured by using the epigastric multiple b value (DWI (b = 02050100200400600800 and 1000s/mm2) from the head to tail of the pancreas. The single index model parameters ADCtotal and the double index model ADCfast, were measured from the head to the tail of the pancreas in each patient. ADCslow and f values were calculated, and the average ADCtotal,ADCfast,ADCslow and f values of each pancreas were calculated. T test of independent samples was used to analyze the age distribution of patients of different genders, and non-parametric Mann-Whitney U test was used to analyze the differences of average values of parameters among different genders. Pearson correlation analysis was used to analyze the correlation between average ADCtotal,ADCfast,ADCslow and f values and age. Results: the mean ADCtotal,ADCfast,ADCslow and f values of normal pancreas were (1.45 卤0.15) 脳 10 ~ (-3) and (13.17 卤4.91) 脳 10 ~ (-3), respectively. (0. 88 卤0. 18) 脳 10-3 mm2/s and (0.370 卤0.063) were lower than those in males [(1. 55 卤0. 17) 脳 10-3, (15. 77 卤7. 83) 脳 10-3, (0. 91 卤0. 15) 脳 10-3 mm2/s and (0.372 卤0.056), respectively]. However, there was no significant difference in the mean value of each parameter between male and female (P0. 05). Pearson correlation analysis showed that the mean ADCtotal,ADCfast and ADCslow values of adult normal pancreas were significantly correlated with age (r = -0.315, respectively). -0.340 and -0.300; P values were 0.017, 0.010 and 0.023); f, respectively. There was no significant correlation between P value and age (r = 0.048, P < 0. 725). Conclusion: the average ADCtotal,ADCfast and ADCslow of adult normal pancreas decrease with age. The effects of age factors on ADCtotal,ADCfast and ADCslow should not be ignored in the study of pancreas related diseases with multiple b DWI.
【作者单位】：第二军医大学附属长海医院影像医学科;
【基金】：国家自然科学基金(81300366) 长海医院“1255”学科建设计划(CH125520800) 长海医院青年科研启动基金(2013002)
【分类号】：R445.2

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