超声血流向量成像评价犬急性心肌缺血时舒张期左心室流体能量损耗

发布时间：2018-12-05 15:47

【摘要】：目的应用超声血流向量成像(VFM)技术可视量化评价急性心肌缺血比格犬舒张期左心室血流的能量损耗变化。方法分别对10只比格犬开胸模型基础和急性缺血状态行VFM检查,存图后导入血流向量标测软件分析获得等容舒张期(T1)、舒张早期(T2)、舒张早期快速充盈(T3)、舒张中期(T4)、舒张晚期心房收缩期(T5)、舒张晚期快速充盈期(T6)左心室整体和基底、中间、心尖水平能量损耗,以及涡旋面积、涡旋循环强度。定性观察并比较两种状态下结果。将缺血状态左心室整体能量损耗与涡旋面积、循环强度进行相关分析。结果缺血状态下舒张期各时相血流的运动方向相对不规则,出现典型的湍流及涡旋的波动,能量损耗的分布区域大且相对离散。与基础状态相比,缺血状态下左心室整体能量损耗均增高,其中在T1、T4、T5、T6,差异有统计学意义(P均0.05)。同样,缺血状态左心室基底、中间水平能量损耗在T1、T4、T5、T6较基础状态增高(P均0.05),缺血状态左心室心尖水平能量损耗在T1、T6上较基础状态增高(P均0.05)。在T4、T5、T6,缺血状态下涡旋面积及循环强度均较基础状态增高(P均0.05),且其分别与左心室整体能量损耗显著相关(r分别为0.61、0.71、0.55和0.79、0.83、0.65,P0.05)。结论急性心肌缺血诱导产生左心室血流湍流和异常的涡旋状态,导致舒张期流体能量损耗的增高,超声血流能量损耗参数能够敏感地反映缺血状态左心室血流动力学的改变。
[Abstract]:Objective to evaluate the energy loss of left ventricular flow in acute myocardial ischemia Beagle canine during diastolic phase by using ultrasound flow vector imaging (VFM). Methods VFM was performed on 10 Beagle dogs with thoracotomy and acute ischemia respectively. The isovolumic diastolic phase (T1), early diastolic phase (T2) and early diastolic rapid filling (T3) were obtained by using flow vector mapping software. Middiastolic (T _ 4), late diastolic atrial contraction (T _ 5), late diastolic rapid filling (T _ 6) left ventricular global and basal, intermediate, apical energy loss, and vortex area, vortex circulation intensity. The results were observed and compared qualitatively. The energy loss of left ventricle was correlated with vortex area and circulation intensity in ischemic state. Results the movement direction of blood flow during diastolic phase was relatively irregular, typical turbulence and vortex fluctuated, and the distribution of energy loss was large and relatively discrete. Compared with the basic state, the whole energy loss of the left ventricle was increased in ischemic state, and the difference was statistically significant in T1T4 and T5T6 (all P 0.05). Similarly, the energy loss at the intermediate level in the left ventricular basement was significantly higher in the ischemic state than in the basal state (P 0.05), and the energy loss at the left ventricular apex in the ischemic state was higher than that in the basal state (P 0.05), and the energy loss of the left ventricular apex in the ischemic state was higher than that in the basal state. The level of T 6 was higher than that of basic state (P 0.05). The vortex area and circulation intensity in ischemic state were significantly higher than those in basic state (P 0.05), and they were significantly correlated with the overall energy loss of left ventricle (r = 0.61-0.71 卤0.55, r = 0.79 卤0.83N 0.65, r = 0.71, P < 0.05). P0.05). Conclusion Acute myocardial ischemia induces turbulence and abnormal vortex of left ventricular blood flow, which leads to the increase of flow energy loss in diastolic phase. The parameters of ultrasonic flow energy loss can sensitively reflect the changes of left ventricular hemodynamics in ischemic state.
【作者单位】：重庆医科大学超声影像学研究所;四川省医学科学院四川省人民医院超声医学研究所;
【基金】：四川省科研院所科技成果转化基金(11010122)
【分类号】：R542.2;R445.1

【共引文献】