体素不相干运动与三维动脉自旋标记在胶质瘤中的对照研究

发布时间：2019-01-09 13:56

【摘要】：目的与三维动脉自旋标记(3D ASL)对照,探讨体素不相干运动(IVIM)在胶质瘤分级中的应用价值。方法搜集胶质瘤患者24例,其中高、低级别胶质瘤患者分别为13例和11例。受试者术前行多b值DWI(MBDWI)和三维伪连续动脉自旋标记(3D PCASL)序列扫描,MB-DWI采用0~3500 s/mm2间共20个b值,采用双指数模型软件处理获得快扩散系数D*(fast ADC),慢扩散系数D(slow ADC)以及快速扩散所占的容积分数f(fraction of fast ADC)三种参数化图像;ASL数据经工作站处理产生的脑血流量(CBF)图。分别测量肿瘤实质区最大CBF值及其相应区域的D*、D、f值,以对侧正常半卵圆中心白质做对照,计算其比值r TBF,r D*,r D,rf。所得数据经统计软件进行组间比较并对CBF值与D*、f值进行相关性分析,P0.05具有统计学意义。结果高级别胶质瘤组的TBF值、r TBF和D*值显著高于低级别胶质瘤组,f值、rf值和D值、r D值正好相反,r D*值无统计学差异;相关分析结果显示肿瘤TBF值与D*值呈正相关性,而与f值呈负相关(P0.05);对侧正常半卵圆中心CBF值和D*值呈正相关性(P0.01),而与f值无相关性(P0.05)。结论 IVIM双指数模型所得D*值、D值及f值在高、低级别胶质瘤中存在统计学差异,在评估脑胶质瘤血流灌注方面D*值与ASL结果之间有较好的相关性。
[Abstract]:Objective to investigate the value of voxel incoherent motion (IVIM) in glioma grading compared with 3D ASL. Methods 24 cases of glioma were collected, including 13 cases of high grade gliomas and 11 cases of low grade gliomas. The subjects were scanned with multiple b value DWI (MBDWI) and 3D pseudo-continuous arterial spin labeling (3D PCASL) before operation. MB-DWI was performed with 20 b values between 0 and 3 500 s/mm2, and the fast diffusion coefficient D * (fast ADC), was obtained by using double exponential model software. Slow diffusion coefficient (D (slow ADC) and volume fraction (f (fraction of fast ADC) occupied by rapid diffusion are three parameterized images. ASL data were processed by workstation to produce cerebral blood flow (CBF). The maximum CBF value in the parenchymal region of the tumor and its corresponding region were measured respectively, and the ratio of r TBF,r DU rf was calculated by using the contralateral normal semicircular white matter as the control. The data were compared with each other by statistical software, and the correlation between CBF value and DX value was analyzed, P0.05 was statistically significant. Results the TBF, r TBF and D * values of high grade gliomas were significantly higher than those of low grade gliomas. The values of f, rf and D, r D were opposite, but there was no significant difference in r D * values. Correlation analysis showed that tumor TBF value was positively correlated with D * value, but negatively correlated with f value (P0.05); contralateral normal oval center CBF value and D * value were positively correlated (P0.01), but had no correlation with f value (P0.05). Conclusion the D *, D and f values of IVIM double index model are statistically different in high and low grade gliomas, and there is a good correlation between D * value and ASL results in the evaluation of cerebral glioma perfusion.
【作者单位】：徐州医学院;南京军区南京总医院医学影像科;
【基金】：南京军区南京总医院院内课题资助项目(编号:2013054)
【分类号】：R739.41;R445.2

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