青少年肌阵挛性癫痫初诊患者的fMRI研究

发布时间：2019-01-17 20:23

【摘要】：目的运用f MRI研究新诊断青少年肌阵挛性癫痫患者静息态下的神经网络,探讨其认知功能损伤的病理生理机制。方法对纳入研究的23例新诊断JME患者及23例健康对照组进行全脑rs-f MRI数据采集,采用f ALFF法分析JME患者及健康对照组静息态下脑功能活动特点,并构建脑功能网络分析JME患者的脑网络异常;同时采集JME患者及健康对照组的全脑3D T1WI图像,采用基于曲面的皮层形态学方法,观察JME患者及健康对照组皮层厚度的差异。结果与健康对照组相比较,JME患者f ALFF减低的区域主要分布于左侧内侧额上回、右侧顶下小叶脑区,f ALFF增高的区域主要分布于右侧梭状回、左侧中央前回、左侧中央后回。Re Ho值增加的脑区为左侧颞下回、右侧中央前回,Re Ho值降低的脑区为左侧前扣带回、左侧额叶中部。左眶额部Hub节点消失。皮层厚度减少的区域位于右角回、右颞中回及右颞下回。差异具有统计学意义(P0.01)。结论新诊断青少年肌阵挛性癫痫患者静息态下存在一个额颞叶丘脑皮层网络,这个病理性神经网络对于正常的生理性神经网络功能构成抑制甚至破坏,导致了JME患者在记忆力、注意力和执行能力上的障碍。
[Abstract]:Objective to explore the pathophysiological mechanism of cognitive impairment in juvenile myoclonic epilepsy patients by using f MRI. Methods whole brain rs-f MRI data were collected from 23 newly diagnosed JME patients and 23 healthy controls. The characteristics of brain function under resting state in JME patients and healthy controls were analyzed by f ALFF method. Brain functional network was constructed to analyze the abnormal brain network in patients with JME. At the same time, 3D T1WI images of the whole brain were collected from patients with JME and healthy controls. The cortical thickness of JME patients and healthy controls was observed by the method of cortical morphology based on curved surface. Results compared with the control group, the decrease of f ALFF in patients with JME was mainly located in the left medial superior frontal gyrus, and in the right inferior parietal lobule, the increased, f ALFF was mainly in the right fusiform gyrus, and in the left precentral gyrus. The. Re Ho of left posterior central gyrus was increased in left inferior temporal gyrus, while that of right precentral gyrus decreased in left anterior cingulate gyrus and left middle frontal lobe. The Hub node of the left orbital frontal region disappeared. The regions with reduced cortical thickness were located in the right corner gyrus, right middle temporal gyrus and right inferior temporal gyrus. The difference was statistically significant (P0.01). Conclusion there is a frontal and temporal thalamic cortical network under resting state in newly diagnosed juvenile myoclonic epilepsy patients. This pathological neural network inhibits or even destroys the function of normal physiological neural network, which leads to memory in JME patients. An obstacle to attention and execution.
【作者单位】：兰州大学第二医院癫痫中心;重庆医科大学附属第一医院神经内科;兰州大学第二医院核磁共振科;
【基金】：甘肃省自然科学基金(1107RJZA095)~~
【分类号】：R445.2;R742.1

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