FSD-bSSFP序列在手部动脉非对比增强血管成像中的初步应用

发布时间：2019-01-19 19:54

【摘要】：目的：评价基于血流敏感散相的平衡稳态自由进动序列(balance steady-state freeprecession with flow-sensitive dephasing magnetization preparation, FSD-bSSFP)在手部动脉非对比剂增强磁共振血管成像(Non-enhanced magnetic resonance angiography,NE-MRA)中的应用价值。材料与方法：本研究经山东省医学影像学研究所医学伦理委员会审查通过，所扫描志愿者均签署扫描及动态强化知情同意书。共扫描30名健康志愿者，其中男性16例、女性14例，年龄20-30岁，平均年龄24岁。使用6通道体线圈及脊柱线圈在1.5T磁共振设备上进行以FSD-bSSFP序列为基础的NE-MRA及增强MRA(CE-MRA)手部动脉成像。由2名具有5年以上MRI诊断经验的放射科医师测量两种成像方法获得的手部动脉图像的信噪比(SNR)和对比噪声比(CNR)，，并对两组图像所显示的各血管段、分支清晰度、图像质量进行评分。采用Kappa分析评价两位观察之间的一致性。P0.05作为具有统计学意义的标准。结果: FSD-bSSFP图像的SNR高于CE-MRA的图像(P=0.003)，FSD-bSSFP图像与CE-MRA图像显示手部动脉的CNR无显著性差异(P=0.561)；FSD-bSSFP序列图像质量评分优于CE-MRA(P=0.025)，静脉污染程度低于CE-MRA(P=0.007)；右侧及左侧手部动脉在FSD-bSSFP图像上的清晰度较好，对拇指动脉显示评分高于CE-MRA(P=0.005,0.002)，对末端动脉的显示评分略高于CE-MRA，但差异无明显统计学意义(P=0.095,0.084)，两组图像对尺桡动脉、掌深弓、掌侧总动脉的显示评分之间的差异无统计学意义(P0.05)。结论：与常规使用的对比剂增强血管成像相比，FSD-bSSFP进行非对比剂增强磁共振血管成像明显降低了静脉污染程度，但在末端动脉的显示还需要进一步提高。
[Abstract]:Objective: to evaluate the balance steady-state free precession sequence (balance steady-state freeprecession with flow-sensitive dephasing magnetization preparation, FSD-bSSFP) based on blood flow sensitive phase in non-contrast enhanced magnetic resonance angiography (Non-enhanced magnetic resonance angiography,) of the hand artery. The application value of NE-MRA. Materials and methods: this study was examined and approved by Medical Ethics Committee of Shandong Medical Imaging Institute. A total of 30 healthy volunteers were scanned, including 16 males and 14 females, aged 20 to 30 years, with an average age of 24 years. 6-channel body coil and spinal coil were used to perform NE-MRA and enhanced MRA (CE-MRA) arteriography based on FSD-bSSFP sequence on 1.5T magnetic resonance equipment. Two radiologists with more than 5 years MRI diagnostic experience measured the signal-to-noise ratio (SNR) and contrast noise ratio (CNR),) of the hand artery images obtained by the two imaging methods. Image quality is graded. Kappa analysis was used to evaluate the consistency between the two observations. P0.05 as a statistically significant standard. Results: the SNR of FSD-bSSFP was higher than that of CE-MRA (P0. 003). There was no significant difference in CNR between FSD-bSSFP and CE-MRA (P0. 561). The image quality score of FSD-bSSFP sequence was better than that of CE-MRA (P0. 025), and the degree of venous contamination was lower than that of CE-MRA (P0. 007). The right hand artery and left hand artery were clearly defined on FSD-bSSFP images. The display score of thumb artery was higher than that of CE-MRA (P0. 005 ~ 0. 002), and that of terminal artery was slightly higher than that of CE-MRA,. However, there was no significant difference between the two groups (P < 0.05). There was no significant difference in the display scores of radial and ulnar artery, deep palmar arch and common palmar artery between the two groups (P0.05). Conclusion: compared with conventional contrast agent enhanced angiography, FSD-bSSFP with non-contrast enhanced magnetic resonance angiography can significantly reduce the degree of venous contamination, but the display of terminal arteries needs to be further improved.
【学位授予单位】：泰山医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2

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