静息态功能磁共振对单纯脊髓受累型多发性硬化异常基础脑活动的研究

发布时间：2019-02-12 19:25

【摘要】：目的将单纯脊髓受累的MS（MS patients with simple spinal cordinvolvement, MS-SSC）患者作为一个亚组，用低频振幅(Amplitude oflow-frequency fuctuation, ALFF)探讨此亚组静息态功能磁共振成像是否有基础脑活动变化。方法收集17名MS-SSC患者和16名年龄性别匹配的正常对照，进行静息态功能磁共振成像数据采集，调查两组间ALFF的差异。用静息态功能磁共振成像数据分析工具（Resting-state fMRI Data AnalysisToolkit）对功能磁共振成像数据进行分析和处理。进一步分析MS-SSC患者异常基础脑活动与（Expanded disability status scale, EDSS）的相关性。结果17例患者均无明显脑内病灶，脊髓受累以颈髓最多(16例)，其次是胸髓(8例)，腰髓受累最少（2例）。有7例患者脊髓病灶分布较广，颈胸髓同时受累（5例），颈胸腰髓同时受累（2例），均大于3个椎体节段。MS-SSC患者的fMRI数据与正常组相比，在楔前叶、楔叶、后扣带回、舌叶和梭状回等表现显著的ALFF减少，而MS-SSC患者的脑岛和右侧顶叶（缘上回）有显著的ALFF增多。舌叶的ALFF分析结果与EDSS(expanded disability states scale, EDSS)评分有显著的相关性。结论静息态下MS-SSC患者活动脑区与正常组之间存在差异，，这些差异可能是脊髓损伤引起的脑功能改变，或者归因于现阶段常规结构MRI尚不能检测到的潜在的脑组织损伤。
[Abstract]:Objective to investigate whether the resting functional magnetic resonance imaging (fMRI) of MS (MS patients with simple spinal cordinvolvement, MS-SSC patients with spinal cord involvement is a subgroup with low frequency amplitude (Amplitude oflow-frequency fuctuation, ALFF). Methods 17 MS-SSC patients and 16 age-sex matched normal controls were collected for resting functional magnetic resonance imaging (fMRI) data collection to investigate the difference of ALFF between the two groups. The static functional magnetic resonance imaging data analysis tool (Resting-state fMRI Data AnalysisToolkit) is used to analyze and process the functional magnetic resonance imaging data. To further analyze the correlation between abnormal basic brain activity and (Expanded disability status scale, EDSS) in patients with MS-SSC. Results there were no obvious lesions in the brain in all the 17 patients. The cervical spinal cord was the most involved (16 cases), followed by the thoracic spinal cord (8 cases) and the lumbar spinal cord (2 cases). In 7 cases, the spinal cord lesions were distributed widely, the cervical and thoracic spinal cord were involved simultaneously (5 cases), and the cervical thoracolumbar spinal cord (2 cases) were all larger than 3 vertebrae segments. The fMRI data of the patients with MS-SSC were compared with those of the normal group in the precuneal lobe and the cuneiform lobe. ALFF in the posterior cingulate gyrus, lingual lobe and fusiform gyrus decreased significantly, while ALFF increased significantly in the right parietal lobe and the right parietal lobe (superior marginal gyrus) in patients with MS-SSC. There was a significant correlation between ALFF analysis and EDSS (expanded disability states scale, EDSS) score. Conclusion there are differences between the active brain area and the normal group in MS-SSC patients at rest. These differences may be due to the changes of brain function caused by spinal cord injury or the potential brain tissue damage which can not be detected by conventional MRI at this stage.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2;R744.51

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