基于高分辨力MRI人脑杏仁核的形态测量及功能成像

发布时间：2019-02-15 07:24

【摘要】：目的：为与杏仁核形态改变的相关疾病提供线性测量指标及功能评价指标。方法：自2013年6月-2013年12月招募健康志愿者，受检者均行常规MRI平扫、3D T1扫描和DTI成像,选出符合纳入标准的受检者共188名，其中男性79例，女性109例，年龄20-75岁，平均年龄45.26±13.99岁，中位年龄46岁，并按性别、年龄分组。应用三维体积分析软件手工勾绘ROI，测量杏仁核的体积、厚度和横径，并进行标准化计算。应用Philips自带DTI分析软件Fiber Track/Interaction Mode/Track Single ROI Fibers，冠状位勾画ROI，软件自动生成杏仁核FA值、杏仁核ADC值及杏仁核纤维束数量、纤维束FA值、纤维束ADC值。采用t检验和方差分析分别比较标准化前后性别、侧别、年龄组间杏仁核体积、杏仁核FA值、杏仁核ADC值及杏仁核纤维束数量、纤维束FA值、纤维束ADC值的差异；采用直线回归分别分析标准化前后杏仁核体积与杏仁核厚度、杏仁核横径的线性关系及杏仁核纤维束数量、纤维束FA值、纤维束ADC值与杏仁核体积的线性关系。结果： 1标准化前两侧杏仁核体积、横径、厚度均存在性别间差异(P＜0.05)，男性大于女性；标准化后右侧杏仁核体积及两侧杏仁核横径、厚度均存在性别间差异(P＜0.05)，但为女性大于男性，左侧杏仁核体积无性别间差异(P＞0.05)。 2标准化前后杏仁核的体积、横径、厚度均存在侧别差异(P＜0.02),左侧大于右侧。 3标准化前两侧杏仁核体积第2与第1、3、4、5年龄组间有差异(P＜0.05)，但标准化后年龄分组间没有差异（P＞0.05）,杏仁核厚度、横径在标准化前后各年龄组间没有差异(P＞0.05)。 4杏仁核体积与其横径呈线性正相关，，左侧更显著，右侧相关系数标准化前后分别为r=0.299和0.297,决定系数R2=0.089和0.088，左侧分别为r=0.344和0.374,决定系数R2=0.118和0.140。 5杏仁核体积与其厚度呈线性正相关，右侧相关系数标准化前后分别为r=0.605和0.595,决定系数R2=0.366和0.354，左侧分别为r=0.541和0.535,决定系数R2=0.293和0.286，R2值右侧大于左侧，说明右侧杏仁核的厚度对体积影响较大。 6左侧杏仁核的纤维束数量存在性别差异(P=0.021),男性多于女性。尚不能认为杏仁核FA值、杏仁核ADC值及右侧杏仁核纤维束数量、纤维束FA值、纤维束ADC值存在性别差异(P＞0.05)。 7杏仁核FA值、杏仁核纤维束数量、纤维束FA值存在侧别差异(P＜0.05)，均为左侧大于右侧。还不能认为杏仁核ADC值、杏仁核纤维束ADC值存在侧别差异(P＞0.05)。 8杏仁核FA值、杏仁核ADC值及杏仁核纤维束数量、纤维束FA值、纤维束ADC值在总体样本各年龄组间差异没有统计学意义。 9右侧杏仁核纤维束数量与其体积呈线性正相关，相关系数r=0.151,决定系数R2=0.023，R2值远远小于0.3，说明体积变化对纤维束数量的影响非常小，左侧杏仁核纤维束数量、两侧杏仁核纤维束的FA值、ADC值与体积无明显相关关系。结论：高分辨力MRI能够清晰显示杏仁核形态及探测其生理状态下的变化,可以准确测量杏仁核体积,定量分析其功能状态，为与杏仁核有关疾病的诊断和鉴别诊断提供科学依据。
[Abstract]:Objective: To provide linear measurement index and functional evaluation index for related diseases that change with the form of amygdala. Methods: A total of 188 healthy volunteers were recruited from June 2013 to December 2013. The subjects were treated with conventional MRI flat scan, 3D T1 scan and DTI imaging to select a total of 188 subjects, including 79 male, 109 female, 20-75 years old, average age of 45. 26 and 13.99. At the age of 46, the median age is 46 years and is divided by sex and age. The three-dimensional volume analysis software was applied to draw the ROI by hand, and the volume, thickness and transverse diameter of the amygdala were measured. Calculation. Application of Philips's DTI analysis software Fiber Track/ Direction Mode/ Track Single ROI Fibers, coronal contouring ROI, software automatically generated amygdala FA value, amygdala ADC value, and number of amygdala fiber bundles, fiber bundle FA value, fiber bundle ADC The results of t-test and variance analysis were used to compare the number of amygdala, amygdala and amygdala in the amygdala, the value of the amygdala, the number of the amygdala, the FA value of the fiber bundle, the difference of the value of the fiber bundle ADC. The linear correlation between the size of the amygdala and the amygdala, the transverse diameter of the amygdala, the number of the amygdala fiber bundles, the FA value of the fiber bundle, the value of the fiber bundle ADC and the volume of the amygdala were analyzed by linear regression. Department. Results: The size of the amygdala, the transverse diameter and the thickness of the amygdala in the first two sides were different (P <0.05), the male was larger than that of the female, the size of the amygdala on the right side and the transverse diameter of the amygdala on both sides were different (P <0.05), but it was the female. Sex is greater than that of male and left amygdala without sex (P> 0. 05). The volume, transverse diameter and thickness of the amygdaloid nucleus before and after normalization were different (P <0.02). There was no difference between group 2 and group 1, 3, 4 and 5 (P <0.05), but there was no difference (P> 0.05), amygdala thickness and transverse diameter before and after normalization. The volume of the amygdala was positively correlated with its transverse diameter, the left side was more significant, the correlation coefficient of the right side was r = 0.299 and 0.297, respectively, the coefficient of determination was r = 0.344 and 0.374, and the coefficient of determination of R2 = 0.374 and 0.374, respectively. The volume of amygdala of 0.118 and 0.140. 5 was positively correlated with its thickness, r = 0.605 and 0.595, r = 0.366 and 0.354, respectively. The left side was r = 0.541 and 0.535, and the coefficient of determination of R2 = 0.293 and 0.286, and the right of R2 was greater than that of the left. the thickness of the amygdala had a significant effect on the volume. There was a gender difference in the number of fiber bundles on the left amygdala. P = 0. 021), more men than women. The amygdala value, the amygdala value, and the right amygdala fiber bundle number, the fiber bundle FA value, the fiber bundle ADC, There was a gender difference in the value (P> 0.05). The value of the amygdaloid nucleus, the number of the amygdala fiber bundles and the value of the fiber bundle FA were different. (P <0.05), the left side is greater than the right. It is also not considered that the amygdala ADC value, the amygdala fiber bundle A There was no difference in the DC value (P> 0.05). The value of the amygdala, the ADC value of the amygdala and the number of the amygdala fiber bundles, the FA value of the fiber bundle, the value of the fiber bundle ADC There was no statistical difference between the total sample age groups. The number of the right amygdala fiber bundles was positively correlated with the volume, the correlation coefficient r = 0.151, the coefficient of determination R2 = 0.023, the R2 value was much less than 0.3, the effect of volume change on the number of the fiber bundles was very small, the left side Almond fiber bundle number, amygdala on both sides Conclusion: High-resolution MRI can clearly show the shape of the amygdala and the change of the physiological state of the amygdala, and can measure the volume of the amygdala accurately and quantitatively analyze its functional state.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2

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