MR扩散峰度成像在鉴别高级别胶质瘤与转移瘤中的价值

发布时间：2019-02-18 18:01

【摘要】：目的:探讨磁共振扩散峰度成像(DKI)中的多个参数(MK值、MD值和FA值)在鉴别脑内原发性高级别胶质瘤与单发脑实质内转移瘤的价值。方法:收集2013年1月—2015年5月在我院就诊并经病理确诊的高级别胶质瘤13例,颅内单发转移瘤12例。所有患者均采用常规MRI序列及DKI序列,在肿瘤实质部分及肿瘤周围水肿区分别设置感兴趣区,测量其MK值、MD值和FA值,并与对侧正常脑白质进行标准化校正处理,得到相应标准化参数值MK'值、MD'值、FA'值,采用独立样本t检验对高级别胶质瘤、转移瘤两组中实质区和瘤周区的DKI各参数值进行统计学分析。结果:高级R%胶质瘤的肿瘤实质区和瘤周区MK值、MD值和FA值分别为0.84±0.21、(1.28±30)×10~(-3)mm~2/s、0.26±0.17;1.19±0.26、(1.07±0.22)×10~(-3)mm~2/s、0.28±0.12。颅内不典型转移瘤的肿瘤实质区和瘤周区的MK值、MD值和FA值分别为0.80±0.20、(1.48±0.45)×10~(-3)mm~2/s、0.17±0.12;0.86±0.18、(1.54±0.46)×10~(-3)mm~2/s、0.22±0.14。肿瘤实质区的DKI参数值在胶质瘤和转移瘤间差异无统计学意义,瘤周区MK值和MD值在两者间差异有统计学意义(P均0.05),FA值差异无统计学意义。矫正后的MK'值、MD'值在瘤周区两种肿瘤间具有明显差异(P均0.01),其他矫正后参数均未发现统计学差异。结论:瘤周水肿区MK值、MD值在鉴别高级别胶质瘤与脑转移瘤中具有重要的价值。
[Abstract]:Objective: to evaluate the value of multiple parameters (MK, MD and FA) in (DKI) in differentiating primary high grade gliomas from single intraparenchymal metastases. Methods: from January 2013 to May 2015, 13 cases of high grade gliomas and 12 cases of single intracranial metastases were collected. All the patients were treated by routine MRI sequence and DKI sequence. The regions of interest were set up in the parenchymal part of the tumor and the edema area around the tumor. The values of MK, MD and FA were measured, and standardized correction was performed with the normal white matter of the contralateral brain. The values of MK', MD' and FA' were obtained. The values of DKI parameters in the parenchymal and peri-tumor regions of high-grade gliomas and metastatic tumors were statistically analyzed by t-test. Results: the MK value, MD value and FA value of the parenchymal and peritumorous regions of advanced R% gliomas were 0.84 卤0.21, (1.28 卤30) 脳 10 ~ (-3) mm~2/s,0.26 卤0.17, respectively. 1.19 卤0.26, (1.07 卤0.22) 脳 10 ~ (-3) mm~2/s,0.28 卤0.12. The MK value, MD value and FA value of parenchyma and peri-tumor of atypical intracranial metastases were 0.80 卤0.20, (1.48 卤0.45) 脳 10 ~ (-3) mm~2/s,0.17 卤0.12, respectively. 0.86 卤0.18, (1.54 卤0.46) 脳 10 ~ (-3) mm~2/s,0.22 卤0.14. There was no significant difference in DKI parameters between gliomas and metastatic tumors, but there was no significant difference in MK and MD between tumor parenchyma and metastatic tumors (P < 0. 05, P < 0. 05). There were significant differences in MK' and MD' values between the two kinds of tumors after correction (P0.01), but there was no statistical difference in other parameters after correction. Conclusion: the values of MK and MD in peritumoral edema are important in differentiating high grade gliomas from brain metastases.
【作者单位】：滨州医学院烟台附属医院放射科;
【分类号】：R739.41;R445.2

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