抑郁症脑部扩散峰度成像研究初探
发布时间：2019-04-27 05:05
【摘要】：目的：运用MRI扩散峰度成像(DKI)技术探讨抑郁症患者脑微观结构的变化特点,从影像学的角度为抑郁症的发病机制提供有价值的信息。方法：收集28例新医大一附院临床确诊的抑郁症患者及28例年龄、性别、族别和教育年限相匹配的健康对照者。在常规磁共振平扫的基础上利用扩散峰度扫描技术对受试者进行脑部扫描,将感性兴趣分别设置在双侧额上回、额中回、额下回、双侧颞叶脑白质区、双侧枕叶脑白质区、胼胝体膝部及压部,测定各感兴趣区平均峰度(MK)值、部分各向异性(FA)值及平均扩散(MD)值。结果：病例组双侧颞叶FA值较对照组减低,两组间差异有统计学意义(P0.05),病例组双侧额上回和双侧颞叶MK值较对照组减低,两组间差异有统计学意义(P0.05)：病例组各脑区MD值与对照组比较,差异无统计学意义(P0.05)；病例组双侧额上回、双侧额中回、双侧额下回、胼胝体膝部及压部的FA值与对照组比较,差异无统计学意义(P0.05)；病例组双侧额中回、双侧额下回、双侧枕叶、胼胝体膝部及压部的MK值与对照组比较,差异无统计学意义(P0.05)。结论：磁共振DKI技术反映了抑郁症患者与情感有关的脑区可能存在细微结构的改变,为抑郁症发病机制的研究提供客观的影像学依据。
[Abstract]:Aim: to explore the changes of brain microstructure in patients with depression by using MRI diffusion kurtography (DKI) technique, and to provide valuable information for the pathogenesis of depression from the perspective of imaging. Methods: twenty-eight patients with depression diagnosed clinically in the first affiliated Hospital of New Medical University and 28 healthy controls matched with age, sex, ethnicity and educational years were collected. On the basis of conventional magnetic resonance imaging, diffusion kurtosis scanning technique was used to scan the brain of the subjects. The perceptual interest was located in bilateral superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus, bilateral temporal lobe white matter area and bilateral occipital lobe white matter area, respectively. The average kurtosis (MK), partial anisotropic (FA) and average diffused (MD) were measured in the geniculus and pressure of corpus callosum. Results: the FA value of bilateral temporal lobe in the case group was significantly lower than that in the control group (P0.05). The MK value of the bilateral superior frontal gyrus and bilateral temporal lobe in the case group was lower than that in the control group. The difference between the two groups was statistically significant (P0.05): there was no significant difference in MDvalues between the case group and the control group (P0.05); The FA values of bilateral superior frontal gyrus, bilateral middle frontal gyrus, bilateral inferior frontal gyrus, knee and pressure of corpus callosum were not significantly different from those of the control group (P0.05). The MK values of bilateral middle frontal gyrus, bilateral inferior frontal gyrus, bilateral occipital lobe, geniculus and pressure of corpus callosum in the case group were not significantly different from those in the control group (P0.05). Conclusion: magnetic resonance imaging (DKI) may reflect the subtle structural changes in the brain regions associated with emotion in patients with depression, which provides objective imaging evidence for the study of the pathogenesis of depression.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2
本文编号：2466711
[Abstract]:Aim: to explore the changes of brain microstructure in patients with depression by using MRI diffusion kurtography (DKI) technique, and to provide valuable information for the pathogenesis of depression from the perspective of imaging. Methods: twenty-eight patients with depression diagnosed clinically in the first affiliated Hospital of New Medical University and 28 healthy controls matched with age, sex, ethnicity and educational years were collected. On the basis of conventional magnetic resonance imaging, diffusion kurtosis scanning technique was used to scan the brain of the subjects. The perceptual interest was located in bilateral superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus, bilateral temporal lobe white matter area and bilateral occipital lobe white matter area, respectively. The average kurtosis (MK), partial anisotropic (FA) and average diffused (MD) were measured in the geniculus and pressure of corpus callosum. Results: the FA value of bilateral temporal lobe in the case group was significantly lower than that in the control group (P0.05). The MK value of the bilateral superior frontal gyrus and bilateral temporal lobe in the case group was lower than that in the control group. The difference between the two groups was statistically significant (P0.05): there was no significant difference in MDvalues between the case group and the control group (P0.05); The FA values of bilateral superior frontal gyrus, bilateral middle frontal gyrus, bilateral inferior frontal gyrus, knee and pressure of corpus callosum were not significantly different from those of the control group (P0.05). The MK values of bilateral middle frontal gyrus, bilateral inferior frontal gyrus, bilateral occipital lobe, geniculus and pressure of corpus callosum in the case group were not significantly different from those in the control group (P0.05). Conclusion: magnetic resonance imaging (DKI) may reflect the subtle structural changes in the brain regions associated with emotion in patients with depression, which provides objective imaging evidence for the study of the pathogenesis of depression.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R445.2
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