基于格兰杰因果分析的右额叶肿瘤患者的功能网络研究

发布时间：2019-06-01 08:23

【摘要】：我们基于格兰杰因果(Granger)分析,研究了右额叶肿瘤患者的静息态网络内部脑区的异常变化,从而探讨与右额叶肿瘤相关的病理机制。利用静息态功能磁共振技术,采集8例临床确诊右额叶肿瘤患者和8名正常志愿者的静息态脑功能数据,分别进行低频振荡振幅(ALFF)分析,将得到的额叶肿瘤患者和正常对照组的ALFF值进行双样本T检验,查看额叶肿瘤患者的激活区域,以激活区域作为感兴趣区(ROI),计算ROI之间的Granger残差系数,两组残差系数进行双样本T检验。右额叶肿瘤患者的补充运动区与楔前叶,背外侧额上回与眶内额上回之间的Granger残差系数与正常对照组有明显差异。根据ALFF结果显示,在静息态下右额叶肿瘤患者的额叶功能活动降低,这与额叶肿瘤部分组织的失活有关,而左侧额叶功能活动增强,且右侧背外侧额上回与左侧眶内额上回的因果关系发生明显的转变,可能与左侧额叶代偿作用有关。而补充运动区与楔前叶之间的信息流向发生变化,可能是默认网络对运动区的作用增强引起的。
[Abstract]:Based on Granger causality (Granger) analysis, we studied the abnormal changes in the resting network of patients with right frontolobe tumors, and discussed the pathological mechanism related to right frontalar tumors. The resting brain function data of 8 patients with right frontolobe tumor and 8 normal volunteers were collected by resting functional magnetic resonance imaging (FMRI). The amplitude of low frequency oscillations were analyzed by (ALFF). The ALFFvalues of patients with frontolobe tumors and normal controls were tested by double sample T test, and the activation regions of patients with frontolobe tumors were examined, and the Granger residual coefficients between ROI were calculated by using the activation region as the region of interest (ROI),). The residual coefficients of the two groups were tested by double sample T test. There were significant differences in Granger residual coefficients between the supplementary motor area and the anterior cuneiform lobe, the dorsolateral superior frontalis gyrus and the intraorbital superior frontalis gyrus in the patients with right forehead lobe tumor and the normal control group. According to the results of ALFF, the functional activity of the right frontal lobe decreased in the resting state, which was related to the inactivation of some tissues of the frontolobe tumor, while the functional activity of the left frontal lobe was enhanced. The causality between the right dorsolateral superior frontalis and the left intraorbital superior frontalis changed obviously, which may be related to the compensation of the left frontalis. The change of the information flow direction between the supplementary motion area and the anterior cuneiform lobe may be caused by the enhancement of the effect of the default network on the motion area.
【作者单位】：南京航空航天大学自动化学院;
【基金】：江苏省临床医学科技专项基金资助项目(SBL201230215)
【分类号】：R445.2;R739.41

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