功能磁共振成像观察复发缓解型多发性硬化患者运动相关脑区的局部一致性
发布时间：2019-06-04 02:27
【摘要】：目的采用静息态功能磁共振(rs-fMRI)区域局部一致性(ReHo)技术,观察复发缓解型多发性硬化(RRMS)患者脑局部ReHo值。方法收集19例RRMS患者(RRMS组)与19名年龄、性别相匹配的健康对照者(对照组)行rsfMR和常规MR检查。分别提取两组左、右侧运动相关脑区ReHo值行两样本t检验分析,对RRMS组双侧运动相关脑区ReHo值与患者EDSS评分行相关性分析。结果与正常对照组相比,RRMS患者双侧运动相关脑区ReHo值降低(P0.05,经AlphaSim校正,体素20),患者双侧运动相关脑区ReHo值与EDSS评分均呈负相关(右侧:r=-0.819,P0.05;左侧:r=-0.871,P0.05)。结论 RRMS患者运动相关脑区神经元活动一致性存在减低改变,这种改变可能是患者运动功障碍形成的相关因素之一。
[Abstract]:Objective to observe the local Reho value of patients with recurrent and remission multiple sclerosis (RRMS) by resting functional magnetic resonance imaging (rs-fMRI) region consistent (ReHo) technique. Methods rsfMR and routine MR were performed in 19 RRMS patients (RRMS group) and 19 age and sex matched healthy controls (control group). The ReHo values of left and right motor-related brain regions in the two groups were extracted and analyzed by two-sample t-test, and the correlation between the Reho value of bilateral motor-related brain regions and the EDSS branch of patients in RRMS group was analyzed. Results compared with the normal control group, the Reho value of bilateral motor-related brain regions in RRMS patients decreased (P0.05, corrected by AlphaSim, voxel 20). There was a negative correlation between Reho values and EDSS scores in bilateral motor-related brain regions (right: r 鈮，
本文编号：2492408
[Abstract]:Objective to observe the local Reho value of patients with recurrent and remission multiple sclerosis (RRMS) by resting functional magnetic resonance imaging (rs-fMRI) region consistent (ReHo) technique. Methods rsfMR and routine MR were performed in 19 RRMS patients (RRMS group) and 19 age and sex matched healthy controls (control group). The ReHo values of left and right motor-related brain regions in the two groups were extracted and analyzed by two-sample t-test, and the correlation between the Reho value of bilateral motor-related brain regions and the EDSS branch of patients in RRMS group was analyzed. Results compared with the normal control group, the Reho value of bilateral motor-related brain regions in RRMS patients decreased (P0.05, corrected by AlphaSim, voxel 20). There was a negative correlation between Reho values and EDSS scores in bilateral motor-related brain regions (right: r 鈮，
本文编号：2492408
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