分子探针Tf-SPION在肝癌早期磁共振成像及同步治疗中的应用
发布时间：2019-06-04 10:12
【摘要】：目的探讨分子探针Tf-SPION在肝癌早期磁共振(MR)成像及同步治疗中的应用价值。方法选择40只雄性SD大鼠中的20只随机分为A组与B组各10只,A组经尾静脉注入生理盐水5 mg/kg;B组经尾静脉注入Tf-SPION 5 mg/kg。剩余20只大鼠建立肝癌模型,造模成功随机分为C组与D组各10只,然后进行同步治疗,C组经肝动脉注射生理盐水5 mg/kg,D组经肝动脉注射Tf-SPION 5 mg/kg。SD大鼠在干预后1、4、24 h后分别行腹部磁共振T2横断位扫描,并且计算肿瘤的T2相对信号强度比(RR)。在干预后1、24 h后取病理标本进行普鲁士蓝染色。结果A组与C组在注射生理盐水前后的肿瘤T2 RR无明显差异(P0.05),且组间对比差异也无统计学意义(P0.05)。B组在经尾静脉注入Tf-SPION后T2 RR值有稍微波动,但是无明显差异(P0.05)。D组在经肝动脉注射Tf-SPION后肿瘤T2 RR值明显下降(P0.05)。A组肿瘤细胞内均没有蓝染铁粒子,D组在干预后1、24 h的铁粒子含量明显高于B组,C组在干预后第1小时的铁粒子含量,低于同时间点的B组与D组(P0.05)。结论靶向成像分子探针Tf-SPION在肝癌早期MR成像与同步治疗有很好的高效性与敏感性,可作为一个新途径来评价肝癌同步治疗后疗效。
[Abstract]:Objective to evaluate the value of molecular probe Tf-SPION in early magnetic resonance (MR) imaging and synchronous treatment of hepatocellular carcinoma (HCC). Methods 20 of 40 male SD rats were randomly divided into two groups: group A (n = 10) and group B (n = 10). Group A was injected with normal saline 5 mg/kg;B via tail vein and Tf-SPION 5 mg/kg. was injected through tail vein. The remaining 20 rats were randomly divided into group C (n = 10) and group D (n = 10). The rats in group C were injected with normal saline 5 mg/kg, via hepatic artery. In group D, Tf-SPION 5 mg/kg.SD rats were injected into hepatic artery at 1, 4 and 24 hours after intervention, and abdominal MRI T2 transection scan was performed 24 hours later, and the T2 relative signal intensity ratio of tumor to (RR). Was calculated. The pathological specimens were stained with Prussian blue 24 hours after intervention. Results there was no significant difference in T2 RR between group A and group C before and after injection of saline (P 0.05), and there was no significant difference between groups (P 0.05). There was no significant difference in T2 RR between group A and group C before and after injection of normal saline (P 0.05). There was no significant difference in T2 RR between group A and group C (P 0.05). However, there was no significant difference (P < 0.05). The T2 RR value of tumor in). D group decreased significantly after Tf-SPION injection through hepatic artery (P 0.05). There were no blue iron particles in tumor cells in). A group (P 0.05). The content of iron particles in group D was significantly higher than that in group B at 24 hours after intervention, and the content of iron particles in group C at the first hour after intervention was lower than that in group B and group D at the same time point (P 0.05). Conclusion targeted imaging molecular probe Tf-SPION is highly effective and sensitive in early MR imaging and synchronous treatment of liver cancer, and can be used as a new way to evaluate the curative effect of synchronous treatment of liver cancer.
【作者单位】： 湖北医药学院附属东风医院磁共振室;
【分类号】：R445.2;R735.7
本文编号：2492654
[Abstract]:Objective to evaluate the value of molecular probe Tf-SPION in early magnetic resonance (MR) imaging and synchronous treatment of hepatocellular carcinoma (HCC). Methods 20 of 40 male SD rats were randomly divided into two groups: group A (n = 10) and group B (n = 10). Group A was injected with normal saline 5 mg/kg;B via tail vein and Tf-SPION 5 mg/kg. was injected through tail vein. The remaining 20 rats were randomly divided into group C (n = 10) and group D (n = 10). The rats in group C were injected with normal saline 5 mg/kg, via hepatic artery. In group D, Tf-SPION 5 mg/kg.SD rats were injected into hepatic artery at 1, 4 and 24 hours after intervention, and abdominal MRI T2 transection scan was performed 24 hours later, and the T2 relative signal intensity ratio of tumor to (RR). Was calculated. The pathological specimens were stained with Prussian blue 24 hours after intervention. Results there was no significant difference in T2 RR between group A and group C before and after injection of saline (P 0.05), and there was no significant difference between groups (P 0.05). There was no significant difference in T2 RR between group A and group C before and after injection of normal saline (P 0.05). There was no significant difference in T2 RR between group A and group C (P 0.05). However, there was no significant difference (P < 0.05). The T2 RR value of tumor in). D group decreased significantly after Tf-SPION injection through hepatic artery (P 0.05). There were no blue iron particles in tumor cells in). A group (P 0.05). The content of iron particles in group D was significantly higher than that in group B at 24 hours after intervention, and the content of iron particles in group C at the first hour after intervention was lower than that in group B and group D at the same time point (P 0.05). Conclusion targeted imaging molecular probe Tf-SPION is highly effective and sensitive in early MR imaging and synchronous treatment of liver cancer, and can be used as a new way to evaluate the curative effect of synchronous treatment of liver cancer.
【作者单位】： 湖北医药学院附属东风医院磁共振室;
【分类号】：R445.2;R735.7
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