吸烟和饮咖啡对局部脑血流量短期影响的动脉自旋标记研究
发布时间：2019-06-27 09:07
【摘要】：目的探讨吸烟对正常成年人局部脑血流量(rCBF)产生的短期影响。材料与方法41名青中年健康志愿者(年龄22~55岁,平均年龄36.6±11.8岁)进行吸烟试验,并分为吸烟史组(男21名)和无吸烟史组(男20名),采用3D-ASL磁共振灌注技术定量测量41名志愿者吸烟前后枕叶、额叶、颞叶灰质和丘脑、基底节区rCBF。结果(1)41名志愿者吸烟前后的各脑区rCBF无明显统计学差异(P值均0.05)。(2)21名吸烟史组的吸烟前rCBF低于20名无吸烟史组,且在双侧枕叶、颞叶、丘脑以及左侧基底节区的rCBF差别较大(P值均0.05)。结论基于3D-ASL技术检测吸烟对局部脑灰质血流量的短期影响,吸烟对rCBF并未产生短期影响,而长期吸烟能导致rCBF降低。目的探讨饮咖啡对正常成年人局部脑血流量(rCBF)产生的短期影响。材料与方法19名青年健康志愿者(年龄范围22~27岁,平均年龄24.4±1.4岁)进行咖啡试验,采用3D-ASL磁共振灌注技术定量测量19名志愿者饮用咖啡前后枕叶、额叶、颞叶灰质和丘脑、基底节区rCBF。结果19名志愿者饮用咖啡后,双侧枕叶、额叶、颞叶灰质和丘脑、基底节的rCBF均产生明显降低的急性变化(P值均0.05),且其下降幅度分别为14.5%(右)、16.5%(左)、11.6%(右)、11.7%(左)、17.6%(右)、15.7%(左)、14.0%(右)、14.3%(左)、14.4%(右)、15.4%(左),以右侧颞叶变化最为显著。结论基于3D-ASL技术检测咖啡对局部脑灰质血流量的短期影响,咖啡使rCBF发生降低的急性变化。
[Abstract]:Objective to investigate the short-term effect of smoking on regional cerebral blood flow (rCBF) in normal adults. Materials and methods 41 young and middle-aged healthy volunteers (22 years old, 55 years old, mean age 36.6 卤11.8 years) were divided into smoking history group (21 males) and non-smoking history group (20 males). The occipital lobe, frontolobe, temporal lobe gray matter, thalamus and basal ganglia rCBF. of 41 volunteers before and after smoking were quantitatively measured by 3D-ASL magnetic resonance perfusion technique. Results (1) there was no significant difference in rCBF in each brain area of 41 volunteers before and after smoking (P < 0.05). (2). The rCBF of 21 smoking history groups before smoking was lower than that of 20 non-smoking history groups, and the rCBF in bilateral occipital lobe, temporal lobe, thalamus and left basal ganglia was significantly different (P < 0.05). Conclusion based on 3D-ASL, the short-term effect of smoking on local gray matter blood flow is detected. Smoking has no short-term effect on rCBF, but long-term smoking can lead to the decrease of rCBF. Objective to investigate the short-term effect of coffee drinking on regional cerebral blood flow (rCBF) in normal adults. Materials and methods Coffee test was carried out in 19 young healthy volunteers (age range 22 鈮，
本文编号：2506665
[Abstract]:Objective to investigate the short-term effect of smoking on regional cerebral blood flow (rCBF) in normal adults. Materials and methods 41 young and middle-aged healthy volunteers (22 years old, 55 years old, mean age 36.6 卤11.8 years) were divided into smoking history group (21 males) and non-smoking history group (20 males). The occipital lobe, frontolobe, temporal lobe gray matter, thalamus and basal ganglia rCBF. of 41 volunteers before and after smoking were quantitatively measured by 3D-ASL magnetic resonance perfusion technique. Results (1) there was no significant difference in rCBF in each brain area of 41 volunteers before and after smoking (P < 0.05). (2). The rCBF of 21 smoking history groups before smoking was lower than that of 20 non-smoking history groups, and the rCBF in bilateral occipital lobe, temporal lobe, thalamus and left basal ganglia was significantly different (P < 0.05). Conclusion based on 3D-ASL, the short-term effect of smoking on local gray matter blood flow is detected. Smoking has no short-term effect on rCBF, but long-term smoking can lead to the decrease of rCBF. Objective to investigate the short-term effect of coffee drinking on regional cerebral blood flow (rCBF) in normal adults. Materials and methods Coffee test was carried out in 19 young healthy volunteers (age range 22 鈮，
本文编号：2506665
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