补片在妇产科疾病中的临床应用及其生物相容性

发布时间：2016-11-02 10:45

本文关键词：补片在妇产科疾病中的临床应用及其生物相容性，由笔耕文化传播整理发布。

背景：生物补片是重要的盆底组织替代物,能够替代薄弱受损的盆底筋膜组织,在盆底重建中的应用越来越广泛,但有关其疗效及生物相容性研究却少有报道。目的：探讨生物补片在妇产科疾病中的临床应用及其生物相容性。结果与结论：盆底修复及重建的材料作为盆底组织替代物能替代薄弱受损的盆底筋膜组织,目前大致包括生物材料、人工合成材料两类。各种修补材料均有优缺点。

中国组织工程研究第16卷第12期 2012–03–18出版

Chinese Journal of Tissue Engineering Research March 18, 2012 Vol.16, No.12

补片在妇产科疾病中的临床应用及其生物相容性

宋利

Clinical application and biocompatibility of patch in obstetrics and gynecology diseases

Song Li Abstract

BACKGROUND: Biological patch is an important substitute of pelvic floor tissue, which can replace the impaired pelvic fascia tissue and has been widely used in pelvic floor reconstruction, but its efficacy and biocompatibility remain poorly studied. OBJECTIVE: To study the clinical application and biocompatibility of biological patch in obstetrics and gynecology disease. METHODS: An online computer-based retrieval of PubMed database and VIP database between January 1990 and December 2011 was performed for articles related to clinical application and biocompatibility of biological patch in obstetrics and gynecology disease. English key words were “obstetrics, gynecology diseases, treatment”, and Chinese key words were “patch, gynecologic and obstetric diseases, treatment”. A total of 192 literatures were screened, and 22 documents were eventually involved in the analysis.

RESULTS AND CONCLUSION: Pelvic floor tissue substitutes for pelvic floor repair and reconstruction can replace the impaired pelvic fascia tissue, and can be divided into biological materials and synthetic materials. A variety of repairing materials have their advantages and disadvantages. In all types of implants, autologous tissue, allograft and xenograft are prone to infection, abrasion, poor biocompatibility after implantation, so they are not applicable as the reconstruction materials. The synthetic absorbable patch is strong, easy to use, but prone to infection, rejection and erosion, showing a poor biocompatibility. Synthetic

nonabsorbable patch and acellular patch have low infection rate, few complications, and good biocompatibility. A large-size prospective case-controlled study for a longer follow-up visits are required to determine which kinds of patch materials are optimal and how is long-term efficacy results.

Song L. Clinical application and biocompatibility of patch in obstetrics and gynecology diseases. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(12): 2253-2256. [ ]

摘要

背景：生物补片是重要的盆底组织替代物，，能够替代薄弱受损的盆底筋膜组织，在盆底重建中的应用越来越广泛，但有关其疗效及生物相容性研究却少有报道。

目的：探讨生物补片在妇产科疾病中的临床应用及其生物相容性。

方法：应用计算机检索1990-01/2011-02 PubMed数据库及维普数据库有关生物补片在妇产科疾病中的临床应用及其生物相容性方面的相关文献，英文检索词“obstetrics，gynecology diseases，treatment”，中文检索词为“补片，妇产科疾病，治疗”。检索文献量总计192篇，最终纳入符合标准的文献22篇。

结果与结论：盆底修复及重建的材料作为盆底组织替代物能替代薄弱受损的盆底筋膜组织，目前大致包括生物材料、人工合成材料两类。各种修补材料均有优缺点。在各种类型植入物中，自体组织、同种异体移植物、异种移植物植入后易感染，磨损，生物相容性较差，作为重建材料并不合适。合成的可吸收补片材料坚固，应用方便，但可能发生感染、排斥和侵蚀等并发症，生物相容性较差。合成的不可吸收补片和脱细胞补片感染发生率低，并发症少，生物相容性较好。但应用哪种补片材料更佳及远期疗效等均有待于延长随访时间、大规模前瞻性病例对照研究加以验证。关键词：重度盆腔脏器脱垂；全盆底重建；补片；生物材料；人工合成材料；综述文献 doi:10.3969/j.issn.1673-8225.2012.12.038

宋利. 补片在妇产科疾病中的临床应用及其生物相容性[J].中国组织工程研究，2012，16(12):2253-2256. [ ]

以下特性：①最小的异物反应。②有弹性可弯0 引言曲。③容易缝合。④较好的组织相容性。⑤允许胶原纤维长入。⑥能够使组织永久的修复。盆腔脏器脱垂和压力性尿失禁是严重影响⑦具有较好的张力。⑧能够抗感染。⑨较少的中、老年妇女生活质量的常见病。随着生活水并发症。

平日益提高，关于此类疾病的研究愈加受到重当前，补片材料有以下几种：①合成的不视，盆底重建外科成为一门新兴的学科。常规可吸收补片。②合成的可吸收补片。③自体或治疗盆腔脏器脱垂的手术方式是阴式子宫切除异体移植物。一般来讲，用作重建材料的自体和阴道前、后壁修补，此种方式有较高的复发组织具有以下优点：无黏膜磨损、不存在疾病率[1]。近年来，为降低手术复发率，进行了各种传播的危险，且感染率极低，但可能存在与筋手术方式的探讨，包括补片的应用。根据盆底膜采集相关的并发症，如下肢或腹部的采集性组织修复的特点，理想的盆底重建材料应具有

创伤等。合成材料则具有性质稳定、坚固、应

ISSN 1673-8225 CN 21-1581/R CODEN: ZLKHAH Department of

Obstetrics and Gynecology,

Shenyang Medical College Affiliated Fengtian Hospital, Shenyang 110024, Liaoning Province, China

Song Li, Associate chief physician, Department of Obstetrics and Gynecology,

Shenyang Medical College Affiliated Fengtian Hospital, Shenyang 110024, Liaoning Province, China

Jiaysheny100@ 126.com

Received: 2012-01-15 Accepted: 2012-02-07

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生物材料-生物相容性-补片在妇产科疾病中的临床应用及其生物相容性