急性肺栓塞患者血清中淀粉样蛋白A水平变化的意义

发布时间：2018-02-03 06:00

  本文关键词： SAA 急性肺栓塞 危险分层　出处：《浙江大学》2017年硕士论文　论文类型：学位论文

【摘要】：研究目的:血清淀粉样蛋白 A(serum amyloidA,SAA)与 C-反应蛋白(C-reactive protein,CRP)相似,同样是一种十分重要的炎症指标。但CRP有助于急性肺栓塞的诊断和危险分层,而SAA与急性肺栓塞之间的关系却不明确。本文研究的目的正是要探讨SAA与急性肺栓塞之间存在的关系。研究方法:本研究回顾性收集了 2012年4月至2015年7月在浙江大学医学院附属邵逸夫医院住院诊治期间的71例急性肺栓塞患者和27例健康对照患者的临床资料,包括 SAA、CRP、D-二聚体和 B 型利钠肽(B-type natriuretic peptide,BNP)的血清浓度,以及由心超测出的左室射血分数(Left ventricular ejection fraction,LVEF)和肺动脉收缩压(systolic pulmonary artery pressure,PASP),并对急性肺栓塞和对照组中的SAA水平以及SAA、D-二聚体、CRP、BNP、LVEF、PASP间的相关性进行分析。研究结果:SAA在急性肺栓塞患者组中的浓度显著高于健康对照组患者,而SAA水平增高的程度则与急性肺栓塞的严重程度相关。PASP水平与SAA呈正相关(r=0.330,p0.05),而 LVEF 水平则与 SAA 呈负相关(r=-0.267,p0.05)。结论:SAA有可能作为急性肺栓塞诊断、危险分层以及预后的一个依据。但是这仍然需要进一步的研究证实,同时SAA在急性肺栓塞机制中的作用也有待进一步地阐明。
[Abstract]:Objective: to study the similarity between serum amyloid A (SAA) and C-reactive protein (CRP). CRP is also a very important indicator of inflammation, but it is helpful in the diagnosis and risk stratification of acute pulmonary embolism. The relationship between SAA and acute pulmonary embolism is not clear. The purpose of this study is to explore the relationship between SAA and acute pulmonary embolism. From April 2012 to July 2015, the clinical data of 71 patients with acute pulmonary embolism and 27 healthy control patients who were hospitalized in run run Shaw Hospital, Zhejiang University Medical College. The serum concentrations of SAA, CRP, D-dimer and B-type natriuretic peptide, B-type natriuretic, were included. Left ventricular ejection fraction (left ventricular ejection fraction) was measured by echocardiography. LVEF) and systolic pulmonary artery pressure (PASP). The levels of SAA in acute pulmonary embolism and control group and SAA D- dimer were measured. The results showed that the concentration of PASP in patients with acute pulmonary embolism was significantly higher than that in healthy controls. However, the increase of SAA level was correlated with the severity of acute pulmonary embolism. PASP level was positively correlated with SAA (0.330% p 0.05). However, the level of LVEF was negatively correlated with SAA. Conclusion: LVEF may be used as a diagnosis of acute pulmonary embolism. A basis for risk stratification and prognosis, however, further research is needed, and the role of SAA in the mechanism of acute pulmonary embolism needs to be further clarified.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.5
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本文编号：1486629