1860株老年复治肺结核患者结核分枝杆菌耐药性分析

发布时间：2018-02-24 09:01

本文关键词： 复治肺结核老年结核分枝杆菌耐药性　出处：《中国感染与化疗杂志》2014年06期 　论文类型：期刊论文

【摘要】：目的分析老年复治肺结核患者中分离的结核分枝杆菌(Mycobacterium tuberculosis)的耐药性。方法收集上海市肺科医院2005年1月至2013年12月1 860例老年复治肺结核患者(复治组)分离菌株,对其进行耐药性分析。另选300例同期初治肺结核患者作为对照(初治组)。比较两组患者病原菌的耐药情况。结果复治组男性与女性患者中分离的病原菌对链霉素、利福平、乙胺丁醇、阿米卡星、卷曲霉素和氧氟沙星的耐药率比较,差异有统计学意义(均P0.05)。男性耐多药比率为24.0%(357/1 489),广泛耐药比率为9.8%(146/1 489);女性分别为34.2%(127/371),19.7%(73/371),差异有统计学意义(P0.05)。复治组耐多药比率为26.0%(484/1 860),广泛耐药比率为11.8%(219/1 860);初治组分别为11.3%(34/300)和7.0%(21/300),差异有统计学意义(P0.05)。复治组耐单药比率为20.0%(372/1 860),初治组为41.0%(123/300),差异有统计学意义(P0.05)。结论老年复治肺结核患者耐药率高,且女性患者耐药发生率高于男性;提示有必要加强老年复治肺结核耐药性监测。
[Abstract]:Objective to analyze the drug resistance of Mycobacterium tuberculosism isolated from elderly patients with recurrent pulmonary tuberculosis. Methods strains isolated from 860 elderly patients with recurrent pulmonary tuberculosis from January 2005 to December 1st 2013 were collected. Drug resistance analysis was carried out. Another 300 cases of newly treated pulmonary tuberculosis patients were selected as control group. The drug resistance of pathogenic bacteria was compared between the two groups. Results the pathogenic bacteria isolated from male and female patients in the retreated group were resistant to streptomycin and rifampicin. Comparison of resistance rates of ethambutanol, amikacin, cricrimycin and ofloxacin, The difference was statistically significant (all P 0.05). The multidrug resistance ratio of male was 24.075 / 1489%, the rate of extensive drug resistance was 9.88% 146 / 1 489; the female was 34.2127 / 371C 19.773 / 371g, respectively, the difference was statistically significant (P0.055.The ratio of multidrug resistance in retreated group was 26.00.4841860%, the rate of extensive drug resistance was 11.819% -860%; in the primary treatment group, the ratio of multidrug resistance was 26.0% 4841860%; the rate of extensive drug resistance was 11.819% -860%; in the primary treatment group, the ratio of multidrug resistance was 26.0%; the rate of extensive drug resistance was 11.19% -860%; The difference was statistically significant (P 0.05). The rate of single drug resistance in the retard group was 20.0% 372 / 1 860%, and in the first treatment group it was 41. 0% 123% 300%. The difference was statistically significant (P 0.05). Conclusion the drug resistance rate of the elderly patients with recurrent pulmonary tuberculosis is high. The incidence of drug resistance in female patients was higher than that in men, suggesting that it was necessary to strengthen drug resistance surveillance in elderly patients with recurrent pulmonary tuberculosis.
【作者单位】：同济大学附属上海市肺科医院结核科;
【分类号】：R521

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