不同血清肿瘤标志物在抗结核治疗过程中的变化

发布时间：2018-03-16 16:03

本文选题：血清肿瘤标志物　切入点：继发性肺结核　出处：《基因组学与应用生物学》2017年11期 　论文类型：期刊论文

【摘要】：本研究旨在探讨血清肿瘤标志物糖类抗原CA125、CA199、癌胚抗原(CEA)、肿瘤坏死因子(TNF)、唾液酸(SA)水平在继发性肺结核和结核性胸膜炎患者抗结核治疗过程中的变化。选取2013年3月至2015年6月46例活动性肺结核和42例结核性胸膜炎患者在治疗前、治疗2个月和6个月时收集静脉血,采用Centaur XP化学发光免疫分析法检测血清CA125、CA199、CEA、TNF、SA水平,30名健康体检人员作为对照,实验数据进行统计分析。研究结果表明继发性肺结核患者和结核性胸膜炎患者治疗前患者CA125、CA199、CEA、TNF、SA水平与对照组相比差异显著(p0.01),当治疗后2个月、6个月,各肿瘤标志物水平都不同程度下降,尤其CA125、CA199、TNF、SA水平差异具有统计学意义(p0.01)。两组患者CA125、CA199、TNF、SA的敏感性和特异性较高,与疾病的诊断相关性更为显著。综上所述,血清CA125、CA199、TNF、SA水平可作为了解结核病患者病情进展和评价疗效的指标。
[Abstract]:The aim of this study was to investigate the changes of serum tumor markers CA125, CA125, CA125, CEA, TNFN, sialic acid in the course of anti-tuberculosis treatment in patients with secondary pulmonary tuberculosis and tuberculous pleurisy. From June to June 2015, 46 patients with active pulmonary tuberculosis and 42 patients with tuberculous pleurisy were treated before treatment. Venous blood was collected at 2 and 6 months after treatment. Serum CA125, CA199, TNFN, SA levels were measured by Centaur XP chemiluminescence immunoassay in 30 healthy people as control. The experimental data were statistically analyzed. The results showed that there was a significant difference in the levels of CA125, CA1999, TNFSA between the patients with secondary pulmonary tuberculosis and the patients with tuberculous pleurisy before treatment compared with the control group (P < 0.01). 2 months, 6 months after treatment, there were significant differences in the levels of TNFSA between the two groups. The level of TNFSA in CA125 / CA1999 / TNFSA was significantly lower than that in CA125 / CA199TNFSA, and the sensitivity and specificity of TNFSA in CA125 / CA1999 / TNFSA were higher than those in CA125 / CA199 / TNFSA, and the correlation between TNFSA and the diagnosis of the disease was more significant. Serum CA125, CA199 and TNFN SA levels can be used as an index to understand the disease progression and evaluate the curative effect of TB patients.
【作者单位】：广东省梅州市人民医院感染科;广东省梅州市人民医院检验科;广东省梅州市人民医院呼吸内科;
【分类号】：R521

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