呼吸过滤器对一口气法肺弥散功能检查的影响

发布时间：2018-03-24 14:36

本文选题：肺功能　切入点：弥散功能　出处：《中国实用内科杂志》2014年S1期

【摘要】：目的探讨一次性呼吸过滤器对一口气呼吸法肺一氧化碳弥散功能检查结果的影响。方法采用自身随机交叉对照试验,对16名受试者进行一口气弥散功能测定,比较应用与不应用一次性呼吸过滤器(Microgard,美国Carefusion公司)测定一口气弥散功能的差异。测试过程及质量控制按照ATS/ERS的一口气呼吸法肺一氧化碳弥散功能测定标准进行。主要观察指标为肺一氧化碳弥散量(DLCO),取两次或两次以上可接受测试的均值记录,测定数值以均数±标准差来表示,组间比较采用配对t检验,P0.05为统计学有差异。结果 16例受试者完成试验。其中男11例,女5例,年龄21~80岁,平均(21.50±18.17)岁。一口气弥散功能指标DLCO的基线值为(5.83±2.03)mol/(min·kPa),应用一次性呼吸过滤器后,DLCO为(5.92±1.93)mol/(min·kPa),应用过滤器后DLCO值的平均差异分别为(0.30±0.34)mol/(min·kPa)(P=0.117),组间差异无统计学意义。16例受试者应用过滤器前后肺弥散功能结果诊断的一致率为100%。结论尽管应用Microgard呼吸过滤器后,DLCO值有所改变,但其差异不具有统计学意义,且其差异在弥散功能指标的个体重复性变化范围以内,并不会对受试者的肺功能临床诊断与评级造成明显的影响,故这种差异无重要的临床意义。总之,过滤器不影响弥散功能测定结果,适于在临床上应用。
[Abstract]:Objective to investigate the effect of one-off breathing filter on the results of pulmonary carbon monoxide dispersion function by one-breath breathing method. To compare the difference between using and not using one-time breath filter Microgard (Carefusion Company, USA) to determine the function of one-breath dispersion. The testing process and quality control were carried out according to the standard of ATS/ERS 's one-breath breathing method for determining the carbon monoxide dispersion function of the lung. The main outcome measures were lung carbon monoxide dispersion volume (DLCOG), and the mean values of two or more acceptable tests were recorded. The measured values were expressed as mean 卤standard deviation. There was statistical difference between the two groups by pairing t test (P0.05). Results Sixteen subjects completed the test, including 11 males and 5 females, aged 2180 years. The average value of DLCO was 21.50 卤18.17 years old. The baseline value of DLCO was 5.83 卤2.03)mol/(min KPA, and that of DLCO was 5.92 卤1.93)mol/(min KPA after one breath filter. The average difference of DLCO value after the application of filter was 0.30 卤0.34)mol/(min KPA 0.117. There was no significant difference between the two groups. The consistent rate of diagnosis of pulmonary diffusivity before and after filter was 100. Conclusion although the Microgard respiratory filter was used, there was a change in DLCO value. However, the difference was not statistically significant, and the difference was within the range of individual reproducibility of the diffusive function index, which did not have a significant effect on the clinical diagnosis and rating of pulmonary function. Therefore, this difference has no important clinical significance. In a word, filter does not affect the results of dispersion function measurement and is suitable for clinical application.
【作者单位】：广州医科大学;广州医科大学附属第一医院广州呼吸疾病研究所(呼吸疾病国家重点实验室呼吸疾病国家临床研究中心);
【分类号】：R563

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