镍钛合金网状气道支架置入术的计算机数值模拟分析

发布时间：2018-03-24 14:47

本文选题：镍钛合金网状气道支架　切入点：肉芽组织过度增生　出处：《生物医学工程研究》2017年02期

【摘要】：气道狭窄已成为一种较为常见的呼吸系统疾病,临床上往往需要进行气道支架置入术以实现气道的快速扩张,缓解患者的呼吸困难。但支架置入后常会出现肉芽组织过度增生的现象,严重的会造成气道的再狭窄。基于"应力-生长"关系的理论,肉芽组织的过度增生可能与局部力学环境的改变相关,特别是支架对气道壁的应力刺激。为此,研究将针对镍钛合金网状气道支架置入术展开计算机数值模拟,以分析支架置入前后局部力学环境的改变。结果显示气道支架置入后,狭窄处壁面的局部应力环境发生了显著的改变,其壁面的扩张应力明显升高且应力集中的现象较为严重。我们认为显著改变的局部应力环境可能是造成气道肉芽组织过度增生的因素之一。
[Abstract]:Airway stenosis has become a common respiratory disease, clinically often requires the rapid expansion of airway stenting for airway, relieving dyspnea in patients with stent implantation. But often lead to excessive proliferation of granulation tissue of the phenomenon, serious will cause airway restenosis. Stress and growth based on the theory of relationship ", hyperplasia of granulation tissue may be related to the local mechanical environment changes, especially the stress stimulation on the airway wall bracket. Therefore, the research will start for nickel titanium alloy mesh airway stenting numerical simulated analysis, to change the local mechanical environment. The results showed that airway stent implantation after stent implantation, the stenosis of local wall should be changed significantly stress environment, the wall surface of the extensional stress increased significantly and the stress concentration phenomenon is more serious. We think that the significant The changing local stress environment may be one of the factors that cause hyperproliferation of airway granulation tissue.

【作者单位】：常州大学生物医学工程与健康科学研究院常州市呼吸医学工程重点实验室;
【基金】：国家自然科学基金资助项目(11472062,11532003)
【分类号】：R56;TP391.9

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