重症肺炎患者D-二聚体、纤维蛋白原、IL-6水平变化及其临床意义

发布时间：2018-04-01 08:06

本文选题：重症肺炎　切入点：D-二聚体　出处：《中国呼吸与危重监护杂志》2017年01期

【摘要】：目的探讨重症肺炎患者中D-二聚体、纤维蛋白原、白细胞介素-6(IL-6)的水平变化及在临床中的应用价值。方法采用回顾性分析的方法,选取2014年10月至2016年3月我院呼吸内科确诊的78例重症肺炎患者、78例普通社区获得性肺炎患者以及同期78例正常体检者,分别收集患者入院时和正常体检者血清中的D-二聚体、纤维蛋白原和IL-6。根据预后将重症肺炎患者分为痊愈组与病死组两个亚组。分析D-二聚体、纤维蛋白原、IL-6在三组中差异、在病死组与痊愈组中的差异,以及与肺炎严重度评分(PSI评分)及其相互之间的相关性。结果重症肺炎组中D-二聚体、纤维蛋白原、IL-6明显高于其他两组(P0.05),普通肺炎组高于正常组(P0.05);病死组D-二聚体、纤维蛋白原、IL-6均较痊愈组高(P0.05);重症肺炎组D-二聚体、纤维蛋白原、IL-6均与PSI评分呈正相关性(r_1=0.765,P0.05;r_2=0.736,P0.05;r_3=0.675,P0.05);且两两之间均呈正相关性(r_(12)=0.654,P0.05;r_(13)=0.532,P0.05;r_(23)=0.524,P0.05)。结论根据重症肺炎患者中D-二聚体、纤维蛋白原、IL-6水平变化可评估重症肺炎病情严重程度,并判断患者预后情况。
[Abstract]:Objective to investigate the changes of D-dimer, fibrinogen, interleukin-6 (IL-6) levels in patients with severe pneumonia and their clinical value. From October 2014 to March 2016, 78 patients with severe pneumonia and 78 patients with general community-acquired pneumonia and 78 normal physical examination patients were selected to collect the serum D-dimer of the patients at admission and normal examination, respectively. According to the prognosis, the patients with severe pneumonia were divided into two subgroups: cured group and dead group. The difference of D-dimer and fibrinogen IL-6 in the three groups and the difference between the dead group and the cured group were analyzed. Results D- dimer and fibrinogen IL-6 in severe pneumonia group were significantly higher than those in other two groups (P0.05, P0.05, P0.05, D- dimer, D- dimer and D- dimer in normal pneumonia group, respectively) and the correlation with PSI score and PSI score in severe pneumonia group, and the relationship between D- dimer and fibrinogen IL-6 in severe pneumonia group was significantly higher than that in the other two groups. The levels of IL-6 in fibrinogen were significantly higher than those in the cured group (P 0.05); in severe pneumonia, the levels of D- dimer, fibrinogen and IL-6 were positively correlated with PSI score. Conclusion according to the D- dimer, 0. 654P0. 05p 0. 055 in the patients with severe pneumonia, there is a positive correlation between the two groups. Conclusion in severe pneumonia patients, there is a positive correlation between D- dimer, P0. 024, and P0. 05. 05. conclusion according to the D- dimer in patients with severe pneumonia, there is a positive correlation between them. The change of fibrinogen IL-6 level can evaluate the severity of severe pneumonia and judge the prognosis of the patients.
【作者单位】：郑州大学第二附属医院呼吸内科;
【分类号】：R563.1

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